Protein: ENSP00000323421
Gene: SMC1A

LinkedOmicsKB © 2022-2023 Zhang Lab

SMC1A:
structural maintenance of chromosomes 1A

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S358EERMEEESQSQGRDL81766-2810----54109449-4019226
S360RMEEESQSQGRDLTL1074569-42152044-7947645951495898332537
T366QSQGRDLTLEENQVK188-------------------
T460KKLEGELTEEVEMAK19----------------72--
Y611HIKKALQYACGNALV19------------------72
S951KGTMDDISQEEGSSQ72036---999---5046108122--402
S956DISQEEGSSQGEDSV1088853-6046121489-67408476797341838147618
S957ISQEEGSSQGEDSVS1062354-2421454545-4025403523193696730587
S962GSSQGEDSVSGSQRI6130----29338---54887---1612
S964SQGEDSVSGSQRISS217--44------54--------
Showing 1 to 10 of 13 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S358EERMEEESQSQGRDL4e-12-2.1e-4------1e-9-
S360RMEEESQSQGRDLTL3.5e-50----6.3e-182.3e-201.7e-12-1.1e-6-
T366QSQGRDLTLEENQVK-----------
T460KKLEGELTEEVEMAK-----------
Y611HIKKALQYACGNALV-----------
S951KGTMDDISQEEGSSQ-0.3------0.3----
S956DISQEEGSSQGEDSV0.056--0.14--0.510.0480.61-0.60.013
S957ISQEEGSSQGEDSVS3.1e-12-0.113.2e-3-1.8e-62.4e-40.081-0.019-
S962GSSQGEDSVSGSQRI2.3e-3--2.3e-3-------
S964SQGEDSVSGSQRISS-----------
Showing 1 to 10 of 13 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationCCRCCS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationCOADS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationGBMS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationHNSCCS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationLSCCS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationLUADS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationOVS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationPDACS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylationUCECS358S360T366T460Y611S951S956S957S962S964S966S970S971proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.