UBE2O: ubiquitin conjugating enzyme E2 O
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
7un3 chain A
7un6 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S73 VSGRYRGS VHFGLVR 4 249 21 - - - - - 82 - - - 35 32 43 36 - - - - - - S87 RLIHGEDS DSEGEEE 10 701 17 - 103 80 24 21 46 - 96 55 30 28 19 16 7 2 100 42 11 4 S89 IHGEDSDS EGEEEGR 10 675 8 - 3 3 77 84 9 - 96 55 10 10 28 24 15 4 100 42 89 18 S98 GEEEGRGS SGCSEAG 9 410 21 - 29 20 8 10 57 - - - 64 56 41 36 5 1 11 4 42 5 S99 EEEGRGSS GCSEAGG 7 149 8 - 4 4 12 15 7 - - - 10 8 13 12 46 10 - - - - S102 GRGSSGCS EAGGAGH 3 67 - - - - 4 5 - - - - - - - - 44 8 - - 6 - S115 GHEEGRAS PLRRGYV 8 477 - - - - 69 72 62 - 39 23 30 26 23 20 81 18 4 2 8 - S161 RHMRSTDS QCGTVID 2 15 6 - - - - - - - - - - - 5 4 - - - - - - S322 PGGTDSVS PPPSVIT 7 128 21 - 4 4 - - 18 - 6 3 15 14 4 4 - - - - 26 9 S381 NCAQGEGS MAKKVKR 3 123 - - - - - - 27 - - - 43 38 - - - - - - 11 4
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S73 VSGRYRGS VHFGLVR -0.96 - - - - - 0.64 -0.59 - - - S87 RLIHGEDS DSEGEEE -0.031 - -1.9e-4 0.1 - 6.1e-3 0.5 - - -7.8e-10 - S89 IHGEDSDS EGEEEGR 0.015 - - 1.4e-4 - 6.1e-3 - 1.8e-3 - -7.8e-10 0.054 S98 GEEEGRGS SGCSEAG 5.2e-3 - -8.2e-6 - - - 2.5e-12 0.022 - - - S99 EEEGRGSS GCSEAGG -0.19 - - - - - - - -0.19 - - S102 GRGSSGCS EAGGAGH - - - - - - - - - - - S115 GHEEGRAS PLRRGYV 3.1e-10 - - 1.6e-8 - 2.4e-3 0.4 0.069 6.4e-3 - - S161 RHMRSTDS QCGTVID - - - - - - - - - - - S322 PGGTDSVS PPPSVIT - - - - - - - - - - - S381 NCAQGEGS MAKKVKR 3.2e-11 - - - - - 3.1e-11 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S73
S87
S89
S98
S99
S102
S115
S161
S322
S381
S399
S401
S407
S411
S425
S429
S431
T435
S439
S441
S475
T488
T491
S493
S497
S499
S500
S515
S777
T782
T828
T834
S836
T838
S839
S896
T906
S1168
S1178
S1180
S1196
S1199
S1201
S1220
S1240
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation CCRCC S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation COAD S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation GBM S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation HNSCC S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation LSCC S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation LUAD S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation OV S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation PDAC S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation UCEC S73 S87 S89 S98 S99 S102 S115 S161 S322 S381 S399 S401 S407 S411 S425 S429 S431 T435 S439 S441 S475 T488 T491 S493 S497 S499 S500 S515 S777 T782 T828 T834 S836 T838 S839 S896 T906 S1168 S1178 S1180 S1196 S1199 S1201 S1220 S1240 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S73
S87
S89
S98
S99
S102
S115
S161
S322
S381
S399
S401
S407
S411
S425
S429
S431
T435
S439
S441
S475
T488
T491
S493
S497
S499
S500
S515
S777
T782
T828
T834
S836
T838
S839
S896
T906
S1168
S1178
S1180
S1196
S1199
S1201
S1220
S1240
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S73
S87
S89
S98
S99
S102
S115
S161
S322
S381
S399
S401
S407
S411
S425
S429
S431
T435
S439
S441
S475
T488
T491
S493
S497
S499
S500
S515
S777
T782
T828
T834
S836
T838
S839
S896
T906
S1168
S1178
S1180
S1196
S1199
S1201
S1220
S1240
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.