Protein: ENSP00000323889
Gene: TRIM25

LinkedOmicsKB © 2022-2023 Zhang Lab

TRIM25:
tripartite motif containing 25

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T26PFKEPVTTPCGHNFC117------------------125
T40CGSCLNETWAVQGSP383--------41235554------
S46ETWAVQGSPYLCPQC5165------44-39231515----84134
T91EPPADVWTPPARASA1099867-3122666063-704378716256831866299518
S100PARASAPSPNAQVAC101553122-103809710099-10862108991101018319105449518
S187LVEHKTCSPASLSQA724548-------106393531287152285
S190HKTCSPASLSQASAD279------------1816----387
S192TCSPASLSQASADLE824115---729-6325225042186--2412
Y278NSKFDTIYQILLKKK2113----------19184036------
S340LIKGIHQSTIDLKNE221------------54----12-
Showing 1 to 10 of 17 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T26PFKEPVTTPCGHNFC-----------
T40CGSCLNETWAVQGSP2.1e-3----2.1e-3-----
S46ETWAVQGSPYLCPQC0.083----0.083-----
T91EPPADVWTPPARASA0.43-9.3e-3-7.1e-3-0.011-1.1e-3-0.75-0.550.070.031
S100PARASAPSPNAQVAC3.2e-23-6.9e-30.03-2.4e-30.0291.6e-70.0595.8e-127.1e-5
S187LVEHKTCSPASLSQA-0.017------0.047-0.17---
S190HKTCSPASLSQASAD-----------
S192TCSPASLSQASADLE0.64-----3.7e-3-0.19---0.44
Y278NSKFDTIYQILLKKK0.91------0.91---
S340LIKGIHQSTIDLKNE-----------
Showing 1 to 10 of 17 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationCCRCCT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationCOADT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationGBMT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationHNSCCT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationLSCCT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationLUADT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationOVT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationPDACT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylationUCECT26T40S46T91S100S187S190S192Y278S340T405S428S429S433T434S435S546proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.