Protein: ENSP00000324636
Gene: VRK3

LinkedOmicsKB © 2022-2023 Zhang Lab

VRK3:
VRK serine/threonine kinase 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S55SKRGLNSSFETSPKK373------------442252810--
T58GLNSSFETSPKKVKW34325---------------41112
S59LNSSFETSPKKVKWS9681--43596628-754424233938551376338318
S71KWSSTVTSPRLSLFS936648-3223--9-2214101032285513299239
S82SLFSDGDSSESEDTL918315-1716191728-64151498--51-9
S83LFSDGDSSESEDTLS1075590-9572352889-321939354440711479018
T104GSGSRPPTPKSSPQK101304103-9176818981-9151103959285491086376618
S115SPQKTRKSPQVTRGS613126-333330----55--13373--
S122SPQVTRGSPQKTSCS735180-1112--35-51291515----29124715
S136SPQKTRQSPQTLKRS101324122-85649710053-7443888210696831881367818
Showing 1 to 10 of 12 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S55SKRGLNSSFETSPKK-0.037---------0.037-
T58GLNSSFETSPKKVKW-----------
S59LNSSFETSPKKVKWS1.2e-27--2.4e-7-9.7e-87.1e-104.1e-60.0110.143.8e-4
S71KWSSTVTSPRLSLFS-0.24-4.3e-4--0.91--1.2e-4-0.031--
S82SLFSDGDSSESEDTL-----------
S83LFSDGDSSESEDTLS1.7e-4-0.920.23--0.0391e-80.097--9.5e-3
T104GSGSRPPTPKSSPQK9.4e-69-3.7e-115.1e-11-3.8e-154e-307e-151.1e-6-0.873.7e-6
S115SPQKTRKSPQVTRGS3.8e-7--3.8e-7-------
S122SPQVTRGSPQKTSCS0.037----6.6e-7----0.29-0.77
S136SPQKTRQSPQTLKRS3.7e-72-0.929.3e-18-2.1e-92.3e-274.7e-261e-74.2e-71.2e-5
Showing 1 to 10 of 12 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationCCRCCS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationCOADS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationGBMS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationHNSCCS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationLSCCS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationLUADS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationOVS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationPDACS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylationUCECS55T58S59S71S82S83T104S115S122S136T139S148proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.