METAP2: methionyl aminopeptidase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1b59 chain A
1b6a chain A
1bn5 chain A
1boa chain A
1kq0 chain A
1kq9 chain A
1qzy chain A
1r58 chain A
1r5g chain A
1r5h chain A
1yw7 chain A
1yw8 chain A
1yw9 chain A
2adu chain A
2ea2 chain A
2ea4 chain A
2ga2 chain A
2oaz chain A
5cls chain A
5d6e chain A
5d6f chain A
5jfr chain A
5jhu chain A
5ji6 chain A
5lyw chain A
5lyx chain A
6qed chain A
6qef chain A
6qeg chain A
6qeh chain A
6qei chain A
6qej chain A
7a12 chain A
7a13 chain A
7a14 chain A
7a15 chain A
7a16 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S45 KRRKKKKS KGPSAAG 2 63 37 - - - - - - - - - 14 12 - - - - - - - - S49 KKKSKGPS AAGEQEP 8 248 29 - 12 11 - - 36 - 14 6 40 38 4 5 - - 21 9 11 12 S60 EQEPDKES GASVDEV 9 419 41 - 21 20 18 9 18 - 73 42 50 46 8 8 - - 4 2 54 5 S63 PDKESGAS VDEVARQ 8 324 34 - 21 20 14 13 27 - 45 26 25 24 14 12 - - - - 35 14 S74 VARQLERS ALEDKER 2 34 - - - - - - - - - - 5 5 - - - - - - 18 6
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S45 KRRKKKKS KGPSAAG - - - - - - - - - - - S49 KKKSKGPS AAGEQEP -0.71 - - - - - -0.71 - - - - S60 EQEPDKES GASVDEV 0.004 - 3.2e-4 - - -3.2e-7 7.9e-11 - - - - S63 PDKESGAS VDEVARQ 7.4e-5 - 3.2e-4 - - 0.38 7.2e-4 - - - 0.94 S74 VARQLERS ALEDKER - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S45
S49
S60
S63
S74
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S45 S49 S60 S63 S74 protein RNA SCNV methylation CCRCC S45 S49 S60 S63 S74 protein RNA SCNV methylation COAD S45 S49 S60 S63 S74 protein RNA SCNV methylation GBM S45 S49 S60 S63 S74 protein RNA SCNV methylation HNSCC S45 S49 S60 S63 S74 protein RNA SCNV methylation LSCC S45 S49 S60 S63 S74 protein RNA SCNV methylation LUAD S45 S49 S60 S63 S74 protein RNA SCNV methylation OV S45 S49 S60 S63 S74 protein RNA SCNV methylation PDAC S45 S49 S60 S63 S74 protein RNA SCNV methylation UCEC S45 S49 S60 S63 S74 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S45
S49
S60
S63
S74
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S45
S49
S60
S63
S74
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.