CASKIN2: CASK interacting protein 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ke9 chain A
4is7 chain A
5l1m chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T252 VDVNIRNT YNQTALD 1 8 - - - - - - - - - - - - - - 7 1 - - - - Y253 DVNIRNTY NQTALDI 10 1009 88 - 99 76 10 8 62 - 102 59 102 94 110 101 11 3 28 12 35 9 S327 WKGHIHES QRGTDRI 4 185 - - - - 67 76 18 - - - 5 5 - - 11 3 - - - - S358 IPAARLPS APTPLRP 10 600 45 - 4 3 18 18 18 - 74 46 60 54 56 53 48 11 58 25 - 9 T370 LRPGFSRT PQPPAEE 2 20 - - - - - - - - - - - - 5 4 - - - - 11 - S396 RVGLSPDS PAGDRNS 10 991 96 - 68 48 4 5 99 - 36 20 93 86 88 80 62 14 63 27 84 18 S403 SPAGDRNS VGSEGSV 10 939 54 - 47 44 85 77 99 - 23 13 73 67 9 9 76 16 97 40 92 18 S406 GDRNSVGS EGSVGSI 10 381 66 - 103 80 15 12 10 - 6 4 19 17 15 12 7 2 3 2 6 2 S409 NSVGSEGS VGSIRSA 9 815 66 - 103 80 22 23 46 - 16 12 98 90 90 82 - - 57 24 6 - S471 RPLANCRS GEQIFTQ 10 750 34 - 14 12 59 57 90 - 36 20 30 26 38 37 56 12 89 38 84 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T252 VDVNIRNT YNQTALD - - - - - - - - - - - Y253 DVNIRNTY NQTALDI -5.9e-32 - -0.24 - - -6.7e-5 -3.3e-22 -6.9e-29 - -0.76 - S327 WKGHIHES QRGTDRI -2.5e-7 - - -2.5e-7 - - - - - - - S358 IPAARLPS APTPLRP -1.4e-24 - - - - -4e-13 -5.1e-17 -1.2e-18 -5.8e-3 1.5e-5 - T370 LRPGFSRT PQPPAEE - - - - - - - - - - - S396 RVGLSPDS PAGDRNS -1.4e-19 - -0.52 - - 0.93 -5.7e-9 -1.9e-22 -1.3e-4 -4.0e-4 -0.64 S403 SPAGDRNS VGSEGSV -3.8e-10 - -0.67 -6.5e-9 - -0.1 -4.7e-21 - -0.33 1.9e-7 -4.3e-4 S406 GDRNSVGS EGSVGSI -4.2e-4 - -4.2e-4 - - - - - - - - S409 NSVGSEGS VGSIRSA -5.3e-33 - -8.4e-6 -0.52 - - -2.5e-24 -2.5e-17 - -2.6e-3 - S471 RPLANCRS GEQIFTQ -1.6e-25 - - -1.9e-5 - -2.6e-5 -2.8e-12 -6.8e-18 0.23 -0.065 -3.9e-3
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T252
Y253
S327
S358
T370
S396
S403
S406
S409
S471
T477
S673
S695
S697
S700
S705
S708
S711
S720
S725
S800
S802
T807
S842
T853
S858
S877
S878
S880
S883
S908
S914
S927
T929
T939
S945
S946
S1135
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation CCRCC T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation COAD T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation GBM T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation HNSCC T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation LSCC T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation LUAD T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation OV T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation PDAC T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation UCEC T252 Y253 S327 S358 T370 S396 S403 S406 S409 S471 T477 S673 S695 S697 S700 S705 S708 S711 S720 S725 S800 S802 T807 S842 T853 S858 S877 S878 S880 S883 S908 S914 S927 T929 T939 S945 S946 S1135 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T252
Y253
S327
S358
T370
S396
S403
S406
S409
S471
T477
S673
S695
S697
S700
S705
S708
S711
S720
S725
S800
S802
T807
S842
T853
S858
S877
S878
S880
S883
S908
S914
S927
T929
T939
S945
S946
S1135
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T252
Y253
S327
S358
T370
S396
S403
S406
S409
S471
T477
S673
S695
S697
S700
S705
S708
S711
S720
S725
S800
S802
T807
S842
T853
S858
S877
S878
S880
S883
S908
S914
S927
T929
T939
S945
S946
S1135
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.