Protein: ENSP00000325827
Gene: SEC16A

LinkedOmicsKB © 2022-2023 Zhang Lab

SEC16A:
SEC16 homolog A, endoplasmic reticulum export factor

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S28PRSVFWASSPYRRRA19------------54------
S29RSVFWASSPYRRRAN10864122-28275482-161183769482681632118918
T65SRQALQSTPLGSSSK2121------------44----9518
S70QSTPLGSSSKSSPPV247------18-----------29-
S73PLGSSSKSSPPVLQG33417-------53--54------
S74LGSSSKSSPPVLQGP91178122-8572606599-10862917410694--59224316
S103HTHARDSSQGPCEPL623175-178----53141397----6416
S122TQPRAHASPFSGALT971753-3531--63-80463432817149112398118
T129SPFSGALTPSAPPGP51147-----18-----1311348--194
T197NPHDGVVTPAASPSL726017-44--18-29161084539----5218
Showing 1 to 10 of 115 rows
102550100
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S28PRSVFWASSPYRRRA-----------
S29RSVFWASSPYRRRAN8.2e-42-0.002---6e-188.3e-222.9e-47.7e-41.1e-6
T65SRQALQSTPLGSSSK0.097---------0.097
S70QSTPLGSSSKSSPPV-----------
S73PLGSSSKSSPPVLQG-----------
S74LGSSSKSSPPVLQGP2.6e-5-3.4e-3-0.63-9.8e-5-0.0481.6e-3--0.313.8e-6
S103HTHARDSSQGPCEPL0.002---------0.002
S122TQPRAHASPFSGALT0.092--0.41---0.0240.180.150.44-2.5e-4
T129SPFSGALTPSAPPGP-----------
T197NPHDGVVTPAASPSL-0.57-----2.8e-7-0.035--0.042
Showing 1 to 10 of 115 rows
102550100
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

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proteinRNASCNVmethylationCCRCCS28S29T65S70S73S74S103S122T129T197S201S203S314S331S342S357S524S534S536T545S559S569S581S587S589S592T593S595T600T605S606S720S774S781S788S957S963S985S1012S1014S1016S1019S1022S1069S1207S1222S1223S1226S1228S1229S1244S1253S1305S1327Y1339S1347S1350S1353S1356S1359S1362S1365S1368S1369S1371S1372S1374S1377S1389Y1390S1398S1413S1414Y1421Y1423T1427S1436S1437T1440S1441S1573S1595S1601T1907S1939S1952T1956S1964T1988S1999S2022S2037S2039S2042T2054S2056T2058S2073T2076S2081S2083S2130S2205S2225T2231S2268S2271S2275S2279S2280S2285S2291S2295S2298S2304proteinRNASCNVmethylation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proteinRNASCNVmethylation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proteinRNASCNVmethylation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proteinRNASCNVmethylationLSCCS28S29T65S70S73S74S103S122T129T197S201S203S314S331S342S357S524S534S536T545S559S569S581S587S589S592T593S595T600T605S606S720S774S781S788S957S963S985S1012S1014S1016S1019S1022S1069S1207S1222S1223S1226S1228S1229S1244S1253S1305S1327Y1339S1347S1350S1353S1356S1359S1362S1365S1368S1369S1371S1372S1374S1377S1389Y1390S1398S1413S1414Y1421Y1423T1427S1436S1437T1440S1441S1573S1595S1601T1907S1939S1952T1956S1964T1988S1999S2022S2037S2039S2042T2054S2056T2058S2073T2076S2081S2083S2130S2205S2225T2231S2268S2271S2275S2279S2280S2285S2291S2295S2298S2304proteinRNASCNVmethylation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proteinRNASCNVmethylationOVS28S29T65S70S73S74S103S122T129T197S201S203S314S331S342S357S524S534S536T545S559S569S581S587S589S592T593S595T600T605S606S720S774S781S788S957S963S985S1012S1014S1016S1019S1022S1069S1207S1222S1223S1226S1228S1229S1244S1253S1305S1327Y1339S1347S1350S1353S1356S1359S1362S1365S1368S1369S1371S1372S1374S1377S1389Y1390S1398S1413S1414Y1421Y1423T1427S1436S1437T1440S1441S1573S1595S1601T1907S1939S1952T1956S1964T1988S1999S2022S2037S2039S2042T2054S2056T2058S2073T2076S2081S2083S2130S2205S2225T2231S2268S2271S2275S2279S2280S2285S2291S2295S2298S2304proteinRNASCNVmethylation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proteinRNASCNVmethylation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proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.