Protein: ENSP00000328088
Gene: PAWR

LinkedOmicsKB © 2022-2023 Zhang Lab

PAWR:
pro-apoptotic WT1 regulator

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S9ATGGYRTSSGLGGST4122--1212----7325222120------
S10TGGYRTSSGLGGSTT969767-75601520--12568625248729239649
S15TSSGLGGSTTDFLEE6888---99----10944--4229-
T16SSGLGGSTTDFLEEW723528-2824----5225231816--3015129
T17SGLGGSTTDFLEEWK217--8-------------72--
S108AAPGPRRSEDEPPAA107988-6248707326-2916938682766015513612
S162KLREKRRSTGVVNIP733364---1611--241524224844--53516
T163LREKRRSTGVVNIPA61269-------44551717--32555
S228TVSGRYKSTTSVSEE52128---3942--------5613165294
T229VSGRYKSTTSVSEED19----------54--------
Showing 1 to 10 of 19 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S9ATGGYRTSSGLGGST-3e-16------1.3e-13-3.2e-5---
S10TGGYRTSSGLGGSTT0.58--0.022----4.8e-30.76-3.2e-9-
S15TSSGLGGSTTDFLEE-----------
T16SSGLGGSTTDFLEEW0.92--0.93----2.1e-3--8.9e-4-
T17SGLGGSTTDFLEEWK-----------
S108AAPGPRRSEDEPPAA-1.9e-7--0.01-2.8e-3-0.75-7.7e-19-0.25-0.99-0.14
S162KLREKRRSTGVVNIP-6.1e-4-----0.058-0.016-0.1---
T163LREKRRSTGVVNIPA-----------
S228TVSGRYKSTTSVSEE-0.024---0.002-----0.92--
T229VSGRYKSTTSVSEED-----------
Showing 1 to 10 of 19 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_Akt1/AKT1S2312.4e-18-0.590.115.7e-99.1e-50.0931.6e-40.0125.7e-35.2e-49.1e-3
KINASE-PSP_PKCA/PRKCAS2336.3e-170.016-0.0290.0371.3e-40.0161.8e-78.1e-30.0480.019
KINASE-PSP_PKACA/PRKACAS2312.4e-14-0.290.174.0e-52.5e-50.974.3e-50.0590.821.5e-77.0e-5
PATH-NP_EGFR1_PATHWAYS2592.7e-14-0.330.62--0.30.011.2e-35.4e-5-2.2e-166.3e-7
KINASE-PSP_MAPKAPK2S2314.7e-12--2.2e-77.4e-40.820.024-4.1e-37.1e-40.32
PERT-PSP_EGFS2315.6e-12-0.970.572.8e-62.6e-30.0148.3e-40.0120.575.9e-40.2
PATH-NP_EGFR1_PATHWAYS2312.8e-11-0.790.773.8e-6-0.373.8e-31.3e-30.09-2.1e-53.0e-5
KINASE-PSP_Akt1/AKT1S2335e-110.61-0.728.3e-54.6e-30.0490.0170.0120.0488.2e-40.093
KINASE-PSP_PKACA/PRKACAS2338.4e-110.34-0.0285.1e-51.2e-30.310.148.6e-60.172.9e-40.012
PROGENy: TGFbS2312.8e-90.90.630.0684.6e-40.0280.120.636.5e-32.8e-33.6e-3
Showing 1 to 10 of 4902 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationCCRCCS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationCOADS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationGBMS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationHNSCCS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationLSCCS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationLUADS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationOVS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationPDACS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylationUCECS9S10S15T16T17S108S162T163S228T229T230S231S233Y241S242S259T261S266T267proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.