EIF4ENIF1: eukaryotic translation initiation factor 4E nuclear import factor 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5anr chain C
6f9w chain B
6x2r chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S5 ___MDRRS MGETESG 10 1070 99 - 59 37 11 7 71 - 108 62 98 90 101 93 33 8 56 24 95 18 T9 DRRSMGET ESGDAFL 1 8 8 - - - - - - - - - - - - - - - - - - - S74 HASLYPAS GRSSPVE 10 472 30 - 3 3 28 25 99 - 6 3 20 19 38 31 64 13 10 3 59 18 S77 LYPASGRS SPVESLK 8 218 56 - 21 20 - - 9 - 5 4 25 23 25 20 - - 3 2 5 - S78 YPASGRSS PVESLKK 10 1409 97 - 48 41 93 95 99 - 108 62 104 95 106 97 83 19 105 44 95 18 S82 GRSSPVES LKKELDT 3 103 13 - - - - - - - - - 30 28 - - - - - - 18 14 S115 DDLDVVLS PQRRSFG 6 252 52 - - - - - 18 - - - 30 26 26 23 12 5 - - 46 14 S120 VLSPQRRS FGGGCHV 3 214 - - - - - - - - 97 55 - - 20 16 22 4 - - - - S138 VSSRRSGS PLEKDSD 10 1450 113 - 99 78 62 72 99 - 108 62 103 94 105 97 83 19 100 43 95 18 S173 FEKDHRLS DKDLRDL 8 911 62 - 23 23 71 72 90 - - - 84 72 92 83 - - 96 42 83 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S5 ___MDRRS MGETESG 0.061 - 1.6e-6 - - 0.059 -0.043 0.7 - 1.0e-4 -1.4e-5 T9 DRRSMGET ESGDAFL - - - - - - - - - - - S74 HASLYPAS GRSSPVE -0.21 - - -2.1e-4 - - 0.084 -0.95 -0.71 - -0.72 S77 LYPASGRS SPVESLK 1.5e-4 - 8.9e-4 - - - 0.087 0.13 - - - S78 YPASGRSS PVESLKK 1.3e-18 - -4.5e-6 1.2e-7 - 0.14 7.3e-27 1.1e-21 -0.51 6.9e-4 -0.74 S82 GRSSPVES LKKELDT 5.6e-12 - - - - - 5.6e-12 - - - - S115 DDLDVVLS PQRRSFG 2.1e-13 - - - - - 8.3e-7 1.1e-3 - - 5.8e-6 S120 VLSPQRRS FGGGCHV 9.7e-7 - - - - 1.2e-10 - 0.63 - - - S138 VSSRRSGS PLEKDSD 1.5e-31 - 1.6e-6 0.011 - 0.47 5.2e-21 7.7e-21 0.1 6.8e-5 0.54 S173 FEKDHRLS DKDLRDL 7.5e-25 - -0.015 1.2e-10 - - 6.1e-22 5.8e-26 - -0.48 0.08
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S5
T9
S74
S77
S78
S82
S115
S120
S138
S173
S201
S213
T215
S301
S342
S345
S347
S349
S351
S352
S353
S356
T357
S374
S379
Y382
S454
T455
S513
S541
S564
S577
S587
T592
S611
S670
S679
S680
S681
S687
S690
S693
S746
S751
S752
T755
S766
T769
T792
S946
S951
S977
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation CCRCC S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation COAD S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation GBM S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation HNSCC S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation LSCC S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation LUAD S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation OV S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation PDAC S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation UCEC S5 T9 S74 S77 S78 S82 S115 S120 S138 S173 S201 S213 T215 S301 S342 S345 S347 S349 S351 S352 S353 S356 T357 S374 S379 Y382 S454 T455 S513 S541 S564 S577 S587 T592 S611 S670 S679 S680 S681 S687 S690 S693 S746 S751 S752 T755 S766 T769 T792 S946 S951 S977 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S5
T9
S74
S77
S78
S82
S115
S120
S138
S173
S201
S213
T215
S301
S342
S345
S347
S349
S351
S352
S353
S356
T357
S374
S379
Y382
S454
T455
S513
S541
S564
S577
S587
T592
S611
S670
S679
S680
S681
S687
S690
S693
S746
S751
S752
T755
S766
T769
T792
S946
S951
S977
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S5
T9
S74
S77
S78
S82
S115
S120
S138
S173
S201
S213
T215
S301
S342
S345
S347
S349
S351
S352
S353
S356
T357
S374
S379
Y382
S454
T455
S513
S541
S564
S577
S587
T592
S611
S670
S679
S680
S681
S687
S690
S693
S746
S751
S752
T755
S766
T769
T792
S946
S951
S977
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.