Protein: ENSP00000328524
Gene: DENND5A

LinkedOmicsKB © 2022-2023 Zhang Lab

DENND5A:
DENN domain containing 5A

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S193TKLQRFNSYDISRDT973317---788399-301720181311831992409518
S431GNLHCSESASKLKRL19------9-------------
S455RNGNIAGSPLHSYEL3123--44--99-----------115
T618IRLLNVRTPTLRTSM726516-4223--89---551615216--189
S739QPKLSNLSPSVIAQT464------27---5544----172
S741KLSNLSPSVIAQTNW3438---------10997------
T833DNRQRKLTSGSLSTS9506--54183591-45274454661297413513
S834NRQRKLTSGSLSTSG732646-54----221444404946--36146-
S836QRKLTSGSLSTSGIL1052030-88132270-1052926332933875317416
S838KLTSGSLSTSGILLD135------35-------------
Showing 1 to 10 of 19 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S193TKLQRFNSYDISRDT0.92--0.52-0.04-0.093--7.7e-52e-13-3.1e-6
S431GNLHCSESASKLKRL-----------
S455RNGNIAGSPLHSYEL-----------
T618IRLLNVRTPTLRTSM0.042-0.042--------
S739QPKLSNLSPSVIAQT-----------
S741KLSNLSPSVIAQTNW-----------
T833DNRQRKLTSGSLSTS-0.04-----8.5e-5--0.20.022-1.7e-4
S834NRQRKLTSGSLSTSG-1.5e-6-----8.6e-3-2.3e-8-0.034-0.47-
S836QRKLTSGSLSTSGIL-4.6e-3------1.8e-4-1.7e-3-0.06-0.52
S838KLTSGSLSTSGILLD-----------
Showing 1 to 10 of 19 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationCCRCCS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationCOADS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationGBMS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationHNSCCS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationLSCCS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationLUADS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationOVS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationPDACS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylationUCECS193S431S455T618S739S741T833S834S836S838T839S840S846S851S1068T1079S1085S1087S1096proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.