PYCR1: pyrroline-5-carboxylate reductase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ger chain A
2ger chain B
2ger chain C
2ger chain D
2ger chain E
2gr9 chain A
2gr9 chain B
2gr9 chain C
2gr9 chain D
2gr9 chain E
2gra chain A
2gra chain B
2gra chain C
2gra chain D
2gra chain E
2izz chain A
2izz chain B
2izz chain C
2izz chain D
2izz chain E
5uat chain A
5uat chain B
5uat chain C
5uat chain D
5uat chain E
5uau chain A
5uau chain B
5uau chain C
5uau chain D
5uau chain E
5uav chain A
5uav chain B
5uav chain C
5uav chain D
5uav chain E
5uaw chain A
5uaw chain B
5uaw chain C
5uaw chain D
5uaw chain E
5uax chain A
5uax chain B
5uax chain C
5uax chain D
5uax chain E
6xoz chain A
6xoz chain B
6xoz chain C
6xoz chain D
6xoz chain E
6xp0 chain A
6xp0 chain B
6xp0 chain C
6xp0 chain D
6xp0 chain E
6xp1 chain A
6xp1 chain B
6xp1 chain C
6xp1 chain D
6xp1 chain E
6xp2 chain A
6xp2 chain B
6xp2 chain C
6xp2 chain D
6xp2 chain E
6xp3 chain A
6xp3 chain B
6xp3 chain C
6xp3 chain D
6xp3 chain E
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S233 QLKDNVSS PGGATIH 1 9 - - - - - - - - 5 4 - - - - - - - - - - S278 MADQEQVS PAAIKKT 3 25 6 - - - - - - - 6 4 - - - - - - - - 7 2 S301 SPAGTALS PSGHTKL 4 91 32 - - - - - - - 21 12 - - 9 8 7 2 - - - - S303 AGTALSPS GHTKLLP 1 9 - - - - - - - - - - - - 5 4 - - - - - - S312 HTKLLPRS LAPAGKD 2 17 - - - - - - - - 5 4 - - - - - - - - 5 3
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S233 QLKDNVSS PGGATIH - - - - - - - - - - - S278 MADQEQVS PAAIKKT - - - - - - - - - - - S301 SPAGTALS PSGHTKL 0.33 - - - - 0.33 - - - - - S303 AGTALSPS GHTKLLP - - - - - - - - - - - S312 HTKLLPRS LAPAGKD - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S233
S278
S301
S303
S312
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S233 S278 S301 S303 S312 protein RNA SCNV methylation CCRCC S233 S278 S301 S303 S312 protein RNA SCNV methylation COAD S233 S278 S301 S303 S312 protein RNA SCNV methylation GBM S233 S278 S301 S303 S312 protein RNA SCNV methylation HNSCC S233 S278 S301 S303 S312 protein RNA SCNV methylation LSCC S233 S278 S301 S303 S312 protein RNA SCNV methylation LUAD S233 S278 S301 S303 S312 protein RNA SCNV methylation OV S233 S278 S301 S303 S312 protein RNA SCNV methylation PDAC S233 S278 S301 S303 S312 protein RNA SCNV methylation UCEC S233 S278 S301 S303 S312 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S233
S278
S301
S303
S312
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S233
S278
S301
S303
S312
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.