- SNN:
- stannin
Lollipop plot
Phosphosites location and occurrence
Structure
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Site
| Sequence | Cohorts | Total | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N |
| S49 | SQSEDEESIVGDGET | 2 | 53 | - | - | - | - | - | - | 45 | - | - | - | - | - | - | - | 7 | 1 | - | - | - | - |
| S66 | PFLLVQYSAKGPCVE | 2 | 98 | - | - | - | - | - | - | 80 | - | - | - | - | - | - | - | - | - | - | - | 7 | 11 |
Tumor and normal comparison
Site
| Sequence | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S49 | SQSEDEESIVGDGET | - | - | - | - | - | - | - | - | - | - | - |
| S66 | PFLLVQYSAKGPCVE | - | - | - | - | - | - | - | - | - | - | - |
Phenotype and mutation association
Signed p-values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
| HALLMARK_KRAS_SIGNALING_DN | S49 | 2.0e-4 | - | - | - | 2.0e-4 | - | - | - | - | - | - |
| HALLMARK_KRAS_SIGNALING_DN | S66 | 1.1e-3 | - | - | - | 1.1e-3 | - | - | - | - | - | - |
| HALLMARK_SPERMATOGENESIS | S66 | 1.2e-3 | - | - | - | 1.2e-3 | - | - | - | - | - | - |
| xcell: B cell plasma | S49 | 2.4e-3 | - | - | - | 2.4e-3 | - | - | - | - | - | - |
| KINASE-PSP_CDK5 | S66 | 2.9e-3 | - | - | - | 2.9e-3 | - | - | - | - | - | - |
| cibersort: T cell follicular helper | S49 | 7.5e-3 | - | - | - | 7.5e-3 | - | - | - | - | - | - |
| HALLMARK_HEDGEHOG_SIGNALING | S66 | 0.012 | - | - | - | 0.012 | - | - | - | - | - | - |
| cibersort: T cell CD8+ | S66 | 0.017 | - | - | - | 0.017 | - | - | - | - | - | - |
| DISEASE-PSP_Alzheimer's_disease | S66 | 0.022 | - | - | - | 0.022 | - | - | - | - | - | - |
| chromosomal instability | S49 | 0.024 | - | - | - | 0.024 | - | - | - | - | - | - |
Cis-association
Kinase association
Signed p-values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
| ACVR1 | S66 | 1.7e-6 | - | - | - | 1.7e-6 | - | - | - | - | - | - |
| MAP2K4 | S66 | 3.9e-6 | - | - | - | 3.9e-6 | - | - | - | - | - | - |
| EPHA7 | S66 | 1.6e-5 | - | - | - | 1.6e-5 | - | - | - | - | - | - |
| CSNK1D | S66 | 2.5e-5 | - | - | - | 2.5e-5 | - | - | - | - | - | - |
| TAOK2 | S66 | 4.9e-5 | - | - | - | 4.9e-5 | - | - | - | - | - | - |
| MINK1 | S66 | 4.9e-5 | - | - | - | 4.9e-5 | - | - | - | - | - | - |
| RPS6KA2 | S66 | 6.2e-5 | - | - | - | 6.2e-5 | - | - | - | - | - | - |
| MARK3 | S66 | 7.7e-5 | - | - | - | 7.7e-5 | - | - | - | - | - | - |
| KSR1 | S66 | 1.3e-4 | - | - | - | 1.3e-4 | - | - | - | - | - | - |
| MAPK1 | S66 | 1.4e-4 | - | - | - | 1.4e-4 | - | - | - | - | - | - |
Phosphatase association
Signed p-values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
| PTPN7 | S66 | -7.6e-6 | - | - | - | -7.6e-6 | - | - | - | - | - | - |
| IMPA2 | S66 | -5.1e-5 | - | - | - | -5.1e-5 | - | - | - | - | - | - |
| PTPN6 | S66 | -8.4e-5 | - | - | - | -8.4e-5 | - | - | - | - | - | - |
| PTPN2 | S66 | -1.1e-4 | - | - | - | -1.1e-4 | - | - | - | - | - | - |
| PTPN12 | S49 | -1.5e-4 | - | - | - | -1.5e-4 | - | - | - | - | - | - |
| PTPN4 | S66 | -1.7e-4 | - | - | - | -1.7e-4 | - | - | - | - | - | - |
| TNS3 | S49 | -2.8e-4 | - | - | - | -2.8e-4 | - | - | - | - | - | - |
| BPGM | S66 | -4.1e-4 | - | - | - | -4.1e-4 | - | - | - | - | - | - |
| PTPN1 | S66 | -5.0e-4 | - | - | - | -5.0e-4 | - | - | - | - | - | - |
| PPIP5K2 | S66 | -5.4e-4 | - | - | - | -5.4e-4 | - | - | - | - | - | - |