STING1: stimulator of interferon response cGAMP interactor 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4ef4 chain A
4ef4 chain B
4ef5 chain A
4emt chain A
4emt chain B
4emu chain A
4emu chain B
4f5d chain A
4f5d chain B
4f5e chain A
4f5w chain A
4f5y chain A
4f5y chain B
4f9e chain A
4f9g chain A
4f9g chain C
4ksy chain A
4loh chain A
4loh chain B
4loi chain A
4loi chain B
4qxo chain A
4qxp chain A
4qxp chain B
4qxq chain A
4qxq chain B
4qxr chain A
4qxr chain B
5bqx chain A
5jej chain C
5jej chain D
5jej chain E
6cff chain A
6cy7 chain A
6dnk chain A
6dxg chain A
6dxl chain A
6dxl chain B
6mx0 chain A
6mx0 chain B
6mx3 chain A
6mx3 chain B
6mxe chain A
6mxe chain B
6nt5 chain A
6nt5 chain B
6o8b chain D
6o8b chain E
6o8c chain D
6o8c chain E
6rm0 chain A
6s26 chain A
6s26 chain B
6s27 chain A
6s86 chain A
6s86 chain B
6ukm chain A
6uku chain A
6ukv chain A
6ukv chain B
6ukw chain A
6ukw chain B
6ukx chain A
6ukx chain B
6uky chain A
6ukz chain A
6ukz chain B
6ul0 chain A
6xf3 chain A
6xf3 chain B
6xf4 chain A
6xf4 chain B
6xnp chain A
6xnp chain B
6y99 chain A
6ydb chain A
6ydz chain A
6yea chain A
6ywa chain A
6ywa chain B
6ywb chain A
6z0z chain A
6z15 chain A
7a90 chain A
7kvx chain A
7kvz chain A
7kw1 chain A
7mhc chain A
7ob3 chain A
7sii chain A
7sii chain B
7sii chain C
7sii chain D
7ssm chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T229 LDKLPQQT GDHAGIK 1 7 - - - - - - - - - - - - - - - - 5 2 - - S322 QEPADDSS FSLSQEV 1 9 - - - - - - - - - - - - 4 5 - - - - - - S345 KEEVTVGS LKTSAVP 6 170 - - 12 2 - - - - 37 25 29 26 9 8 - - 9 4 7 2 S349 TVGSLKTS AVPSTST 1 8 - - - - - - - - - - - - 4 4 - - - - - - S353 LKTSAVPS TSTMSQE 4 50 - - - - 4 5 - - - - - - - - 4 - 21 9 5 2 T354 KTSAVPST STMSQEP 2 47 - - - - 22 14 - - - - - - - - - - 8 3 - - S355 TSAVPSTS TMSQEPE 1 5 - - - - - - - - - - - - - - - - 4 1 - - T356 SAVPSTST MSQEPEL 4 65 - - 4 4 9 9 - - 11 8 10 10 - - - - - - - - S358 VPSTSTMS QEPELLI 6 189 - - 17 8 - - - - 47 24 10 8 31 28 7 - - - - 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T229 LDKLPQQT GDHAGIK - - - - - - - - - - - S322 QEPADDSS FSLSQEV - - - - - - - - - - - S345 KEEVTVGS LKTSAVP -0.13 - - - - 0.35 -2.2e-3 - - - - S349 TVGSLKTS AVPSTST - - - - - - - - - - - S353 LKTSAVPS TSTMSQE - - - - - - - - - - - T354 KTSAVPST STMSQEP 0.99 - - 0.99 - - - - - - - S355 TSAVPSTS TMSQEPE - - - - - - - - - - - T356 SAVPSTST MSQEPEL - - - - - - - - - - - S358 VPSTSTMS QEPELLI -0.009 - - - - -9.8e-5 - 0.84 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T229
S322
S345
S349
S353
T354
S355
T356
S358
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation CCRCC T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation COAD T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation GBM T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation HNSCC T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation LSCC T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation LUAD T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation OV T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation PDAC T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation UCEC T229 S322 S345 S349 S353 T354 S355 T356 S358 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T229
S322
S345
S349
S353
T354
S355
T356
S358
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T229
S322
S345
S349
S353
T354
S355
T356
S358
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.