SF3B1: splicing factor 3b subunit 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2f9d chain P
2f9d chain Q
2f9j chain P
2f9j chain Q
2fho chain A
2peh chain C
2peh chain D
3lqv chain P
3lqv chain Q
4oz1 chain C
5ife chain C
5o9z chain v
5z56 chain 1
5z57 chain 1
5z58 chain 1
5zya chain C
6ah0 chain 1
6ahd chain 1
6en4 chain C
6ff4 chain u
6ff7 chain u
6n3e chain B
6n3f chain D
6qx9 chain B1
6y50 chain u
6y53 chain u
6y5q chain u
7abg chain u
7abh chain u
7abi chain u
7b0i chain C
7b91 chain C
7b92 chain C
7b9c chain C
7dvq chain 1
7evn chain C
7evo chain 1
7omf chain C
7onb chain C
7opi chain C
7q3l chain A
7q4o chain A
7q4p chain A
7sn6 chain C
7sn6 chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S47 DQEIYGGS DSRFAGY 2 19 - - - - - - - - 6 3 5 5 - - - - - - - - S49 EIYGGSDS RFAGYVT 3 19 - - - - - - - - - - 5 4 - - 4 - - - 6 - T61 YVTSIAAT ELEDDDD 1 8 - - - - - - 8 - - - - - - - - - - - - - S73 DDDDYSSS TSLLGQK 2 18 - - 5 4 4 5 - - - - - - - - - - - - - - S75 DDYSSSTS LLGQKKP 1 9 - - - - - - - - - - 5 4 - - - - - - - - S97 LLNDIPQS TEQYDPF 1 18 - - - - - - - - - - - - 9 9 - - - - - - T125 EYKKHRRT MIISPER 2 35 - - - - - - 9 - - - - - - - 21 5 - - - - S129 HRRTMIIS PERLDPF 10 1553 122 - 103 80 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 T142 PFADGGKT PDPKMNA 10 1495 122 - 99 76 96 93 90 - 102 58 108 99 110 101 69 16 100 43 95 18 S190 VVNGAAAS QPPSKRK 3 91 49 - - - - - - - - - 9 8 - - - - - - 12 13
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S47 DQEIYGGS DSRFAGY - - - - - - - - - - - S49 EIYGGSDS RFAGYVT - - - - - - - - - - - T61 YVTSIAAT ELEDDDD - - - - - - - - - - - S73 DDDDYSSS TSLLGQK - - - - - - - - - - - S75 DDYSSSTS LLGQKKP - - - - - - - - - - - S97 LLNDIPQS TEQYDPF - - - - - - - - - - - T125 EYKKHRRT MIISPER - - - - - - - - - - - S129 HRRTMIIS PERLDPF -8e-8 - 1.1e-13 -0.016 - -0.015 -2.3e-8 -0.024 0.024 -9.2e-12 -9.3e-8 T142 PFADGGKT PDPKMNA 4.1e-10 - 4.1e-15 0.12 - -0.011 5.1e-6 1.5e-7 1.2e-3 -6.9e-6 0.023 S190 VVNGAAAS QPPSKRK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S47
S49
T61
S73
S75
S97
T125
S129
T142
S190
S194
T207
T211
S217
T223
T227
S229
T235
S242
T244
T248
S251
T257
S259
T261
T267
T273
T278
S286
S287
T296
T299
T303
S308
T313
S322
T326
T328
S332
T341
S344
S349
T350
T354
T362
T369
T371
T379
S400
Y421
T426
T432
T434
T436
T442
S455
T486
S488
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation CCRCC S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation COAD S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation GBM S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation HNSCC S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation LSCC S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation LUAD S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation OV S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation PDAC S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation UCEC S47 S49 T61 S73 S75 S97 T125 S129 T142 S190 S194 T207 T211 S217 T223 T227 S229 T235 S242 T244 T248 S251 T257 S259 T261 T267 T273 T278 S286 S287 T296 T299 T303 S308 T313 S322 T326 T328 S332 T341 S344 S349 T350 T354 T362 T369 T371 T379 S400 Y421 T426 T432 T434 T436 T442 S455 T486 S488 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S47
S49
T61
S73
S75
S97
T125
S129
T142
S190
S194
T207
T211
S217
T223
T227
S229
T235
S242
T244
T248
S251
T257
S259
T261
T267
T273
T278
S286
S287
T296
T299
T303
S308
T313
S322
T326
T328
S332
T341
S344
S349
T350
T354
T362
T369
T371
T379
S400
Y421
T426
T432
T434
T436
T442
S455
T486
S488
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S47
S49
T61
S73
S75
S97
T125
S129
T142
S190
S194
T207
T211
S217
T223
T227
S229
T235
S242
T244
T248
S251
T257
S259
T261
T267
T273
T278
S286
S287
T296
T299
T303
S308
T313
S322
T326
T328
S332
T341
S344
S349
T350
T354
T362
T369
T371
T379
S400
Y421
T426
T432
T434
T436
T442
S455
T486
S488
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.