KNL1: kinetochore scaffold 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3si5 chain X
3si5 chain Y
4a1g chain E
4a1g chain F
4a1g chain G
4a1g chain H
4nf9 chain A
4nf9 chain B
4nfa chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S32 SILKPPRS PLQDLRG 4 51 8 - - - - - 9 - - - - - - - 22 5 5 2 - - S60 KKNSRRVS FADTIKV 10 855 46 - 24 16 16 11 26 - 108 62 98 89 90 81 63 14 28 10 57 16 T539 VQIAAAPT PEKEMML 5 167 33 - 4 4 - - - - 5 2 49 47 - - - - - - 19 4 S578 ERIQQSLS NPLSISL 2 18 - - - - - - - - 6 3 - - - - 8 1 - - - - S633 ESHSQSKS SSDECEE 1 5 - - - - - - - - - - - - - - - - 3 2 - - S634 SHSQSKSS SDECEEI 2 17 - - 4 4 - - - - 6 3 - - - - - - - - - - S635 HSQSKSSS DECEEIT 2 15 - - 4 4 - - - - - - - - - - - - - - 5 2 S765 LAEPLRKS LSNPTPD 2 18 - - - - - - - - - - 5 5 - - - - - - 6 2 S767 EPLRKSLS NPTPDYC 4 86 - - - - - - - - 7 2 - - - - 15 3 4 1 43 11 S837 KVEKCGKS PIEKSGV 1 28 - - - - - - - - - - 15 13 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S32 SILKPPRS PLQDLRG - - - - - - - - - - - S60 KKNSRRVS FADTIKV 1.3e-66 - 1.3e-6 - - 2.2e-19 2.5e-30 6.9e-28 2.3e-6 4.9e-4 0.24 T539 VQIAAAPT PEKEMML 5.6e-17 - - - - - 5.6e-17 - - - - S578 ERIQQSLS NPLSISL - - - - - - - - - - - S633 ESHSQSKS SSDECEE - - - - - - - - - - - S634 SHSQSKSS SDECEEI - - - - - - - - - - - S635 HSQSKSSS DECEEIT - - - - - - - - - - - S765 LAEPLRKS LSNPTPD - - - - - - - - - - - S767 EPLRKSLS NPTPDYC 1.4e-3 - - - - - - - - - 1.4e-3 S837 KVEKCGKS PIEKSGV - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S32
S60
T539
S578
S633
S634
S635
S765
S767
S837
S956
S1008
T1011
T1013
T1017
T1019
S1039
T1042
S1076
S1675
S1690
S1734
S1773
S1845
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation CCRCC S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation COAD S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation GBM S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation HNSCC S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation LSCC S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation LUAD S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation OV S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation PDAC S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation UCEC S32 S60 T539 S578 S633 S634 S635 S765 S767 S837 S956 S1008 T1011 T1013 T1017 T1019 S1039 T1042 S1076 S1675 S1690 S1734 S1773 S1845 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S32
S60
T539
S578
S633
S634
S635
S765
S767
S837
S956
S1008
T1011
T1013
T1017
T1019
S1039
T1042
S1076
S1675
S1690
S1734
S1773
S1845
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S32
S60
T539
S578
S633
S634
S635
S765
S767
S837
S956
S1008
T1011
T1013
T1017
T1019
S1039
T1042
S1076
S1675
S1690
S1734
S1773
S1845
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.