TDP1: tyrosyl-DNA phosphodiesterase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1jy1 chain A
1mu7 chain A
1mu7 chain B
1mu9 chain A
1mu9 chain B
1nop chain A
1nop chain B
1qzq chain A
1qzq chain B
1rff chain A
1rff chain B
1rfi chain A
1rfi chain B
1rg1 chain A
1rg1 chain B
1rg2 chain A
1rg2 chain B
1rgt chain A
1rgt chain B
1rgu chain A
1rgu chain B
1rh0 chain A
1rh0 chain B
5nw9 chain A
5nw9 chain B
5nwa chain A
5nwa chain B
6dhu chain A
6dhu chain B
6die chain A
6die chain B
6dih chain A
6dih chain B
6dim chain A
6dim chain B
6djd chain A
6djd chain B
6dje chain A
6dje chain B
6djf chain A
6djf chain B
6djg chain A
6djg chain B
6djh chain A
6djh chain B
6dji chain A
6dji chain B
6djj chain A
6djj chain B
6mj5 chain A
6mj5 chain B
6myz chain A
6myz chain B
6mz0 chain A
6mz0 chain B
6n0d chain A
6n0d chain B
6n0n chain A
6n0n chain B
6n0o chain A
6n0o chain B
6n0r chain A
6n0r chain B
6n17 chain A
6n17 chain B
6n19 chain A
6n19 chain B
6w4r chain A
6w4r chain B
6w7j chain A
6w7j chain B
6w7k chain A
6w7k chain B
6w7l chain A
6w7l chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S14 YGRWTISS SDESEEE 1 9 - - - - - - - - - - - - - - - - - - 7 2 S15 GRWTISSS DESEEEK 2 69 - - - - - - - - - - - - 5 4 - - - - 53 7 S18 TISSSDES EEEKPKP 3 90 - - 7 8 - - - - - - - - 5 4 - - - - 61 5 S61 AAHKRKIS PVKFSNT 8 587 32 - 48 38 - - 55 - 30 15 83 76 47 43 - - 60 27 31 2 S79 LPPKRQKS GSQEDLG 3 74 - - - - - - - - - - 14 13 4 4 - - - - 32 7 S81 PKRQKSGS QEDLGWC 6 235 8 - - - - - - - 6 3 64 60 4 4 - - 5 1 62 18 S90 EDLGWCLS SSDDELQ 2 32 24 - - - - - - - - - - - - - - - - - 5 3 S91 DLGWCLSS SDDELQP 5 85 41 - 5 4 - - - - 5 2 10 9 - - - - - - 7 2 S92 LGWCLSSS DDELQPE 6 166 6 - 4 4 - - - - 16 10 10 9 - - - - 5 1 83 18 T147 EEEDEYET SGEGQDI 4 62 37 - - - - - - - - - 5 4 4 4 - - - - 5 3
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S14 YGRWTISS SDESEEE - - - - - - - - - - - S15 GRWTISSS DESEEEK - - - - - - - - - - - S18 TISSSDES EEEKPKP - - - - - - - - - - - S61 AAHKRKIS PVKFSNT 5.5e-35 - 3.5e-6 - - 0.58 2.8e-27 5.3e-20 - 0.016 - S79 LPPKRQKS GSQEDLG - - - - - - - - - - - S81 PKRQKSGS QEDLGWC 1.2e-21 - - - - - 8.2e-14 - - - 1.4e-9 S90 EDLGWCLS SSDDELQ - - - - - - - - - - - S91 DLGWCLSS SDDELQP - - - - - - - - - - - S92 LGWCLSSS DDELQPE 2.5e-9 - - - - - - - - - 2.5e-9 T147 EEEDEYET SGEGQDI - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S14
S15
S18
S61
S79
S81
S90
S91
S92
T147
S148
T496
Y497
S563
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation CCRCC S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation COAD S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation GBM S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation HNSCC S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation LSCC S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation LUAD S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation OV S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation PDAC S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation UCEC S14 S15 S18 S61 S79 S81 S90 S91 S92 T147 S148 T496 Y497 S563 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S14
S15
S18
S61
S79
S81
S90
S91
S92
T147
S148
T496
Y497
S563
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S14
S15
S18
S61
S79
S81
S90
S91
S92
T147
S148
T496
Y497
S563
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.