PTPA: protein phosphatase 2 phosphatase activator
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2g62 chain A
2hv6 chain A
2hv6 chain B
2hv7 chain A
2hv7 chain B
2hv7 chain C
2hv7 chain D
2hv7 chain E
2hv7 chain F
2hv7 chain G
2hv7 chain H
2ixm chain A
4lac chain B
4ny3 chain A
4ny3 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S13 RQPPPDSS EEAPPAT 6 255 - - 45 28 - - 19 - 23 14 10 10 - - - - 65 29 10 2 S320 ISAVPSWS KVNQGLI 1 17 - - - - - - 17 - - - - - - - - - - - - - S357 LPIHPVTS G______ 1 8 - - - - - - - - - - - - - - 7 1 - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S13 RQPPPDSS EEAPPAT -3.3e-7 - -0.051 - - -0.049 - - - -8.3e-7 - S320 ISAVPSWS KVNQGLI - - - - - - - - - - - S357 LPIHPVTS G______ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S13
S320
S357
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S13 S320 S357 protein RNA SCNV methylation CCRCC S13 S320 S357 protein RNA SCNV methylation COAD S13 S320 S357 protein RNA SCNV methylation GBM S13 S320 S357 protein RNA SCNV methylation HNSCC S13 S320 S357 protein RNA SCNV methylation LSCC S13 S320 S357 protein RNA SCNV methylation LUAD S13 S320 S357 protein RNA SCNV methylation OV S13 S320 S357 protein RNA SCNV methylation PDAC S13 S320 S357 protein RNA SCNV methylation UCEC S13 S320 S357 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S13
S320
S357
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S13
S320
S357
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.