LCK: LCK proto-oncogene, Src family tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1bhf chain A
1bhh chain A
1bhh chain B
1cwd chain L
1cwe chain A
1cwe chain C
1fbz chain A
1fbz chain B
1h92 chain A
1ijr chain A
1kik chain A
1lcj chain A
1lck chain A
1lck chain B
1lkk chain A
1lkl chain A
1q68 chain B
1q69 chain B
1qpc chain A
1qpd chain A
1qpe chain A
1qpj chain A
1x27 chain A
1x27 chain B
1x27 chain C
1x27 chain D
1x27 chain E
1x27 chain F
2iim chain A
2of2 chain A
2of4 chain A
2ofu chain A
2ofv chain A
2ofv chain B
2og8 chain A
2og8 chain B
2pl0 chain A
2zm1 chain A
2zm4 chain A
2zyb chain A
3ac1 chain A
3ac2 chain A
3ac3 chain A
3ac4 chain A
3ac5 chain A
3ac8 chain A
3acj chain A
3ack chain A
3ad4 chain A
3ad5 chain A
3ad6 chain A
3b2w chain A
3brh chain C
3brh chain D
3bym chain A
3byo chain A
3bys chain A
3byu chain A
3kmm chain A
3kxz chain A
3lck chain A
3mpm chain A
4c3f chain A
4d8k chain A
5mtm chain A
5mtn chain A
6h6a chain E
6h6a chain H
6h6a chain K
6pdj chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S42 TLLIRNGS EVRDPLV 8 518 34 - - - 37 35 42 - 44 27 67 59 40 38 - - 61 25 7 2 S54 PLVTYEGS NPPASPL 1 9 - - - - 6 3 - - - - - - - - - - - - - - S59 EGSNPPAS PLQDNLV 5 91 - - 4 4 - - - - 23 13 5 4 14 13 - - 8 3 - - S94 QLRILEQS GEWWKAQ 5 62 - - 8 8 6 3 - - 5 4 10 9 4 5 - - - - - - S121 NFVAKANS LEPEPWF 1 8 - - - - - - - - - - 4 4 - - - - - - - - S150 APGNTHGS FLIRESE 1 28 - - - - - - - - - - - - - - - - - - 25 3 Y192 NLDNGGFY ISPRITF 8 510 33 - 21 20 6 3 - - 81 46 59 52 34 32 50 11 44 18 - - Y505 FTATEGQY QPQP___ 10 1140 33 - 86 70 86 91 36 - 108 62 64 57 87 81 14 5 103 44 95 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S42 TLLIRNGS EVRDPLV -0.6 - - -0.3 - -0.035 -0.38 0.51 - 0.027 - S54 PLVTYEGS NPPASPL - - - - - - - - - - - S59 EGSNPPAS PLQDNLV -3.1e-4 - - - - -3.1e-4 - - - - - S94 QLRILEQS GEWWKAQ - - - - - - - - - - - S121 NFVAKANS LEPEPWF - - - - - - - - - - - S150 APGNTHGS FLIRESE - - - - - - - - - - - Y192 NLDNGGFY ISPRITF -0.26 - 0.017 - - 9.6e-3 -6.7e-3 -0.004 0.46 -0.004 - Y505 FTATEGQY QPQP___ -1.5e-3 - 0.18 -0.066 - -3.1e-4 -0.012 -6.3e-5 - 2.0e-6 -0.01
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S42
S54
S59
S94
S121
S150
Y192
Y505
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation CCRCC S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation COAD S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation GBM S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation HNSCC S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation LSCC S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation LUAD S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation OV S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation PDAC S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation UCEC S42 S54 S59 S94 S121 S150 Y192 Y505 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S42
S54
S59
S94
S121
S150
Y192
Y505
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S42
S54
S59
S94
S121
S150
Y192
Y505
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.