GRB2: growth factor receptor bound protein 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1aze chain A
1bm2 chain A
1bmb chain A
1cj1 chain A
1cj1 chain B
1cj1 chain C
1cj1 chain D
1cj1 chain E
1cj1 chain F
1cj1 chain G
1cj1 chain H
1cj1 chain I
1cj1 chain J
1cj1 chain K
1cj1 chain L
1fhs chain A
1fyr chain A
1fyr chain B
1fyr chain C
1fyr chain D
1gcq chain A
1gcq chain B
1gfc chain A
1gfd chain A
1ghu chain A
1gri chain A
1gri chain B
1io6 chain A
1jyq chain A
1jyq chain B
1jyr chain A
1jyu chain A
1qg1 chain E
1tze chain E
1x0n chain A
1zfp chain E
2aoa chain A
2aoa chain B
2aob chain A
2aob chain B
2aob chain C
2aob chain D
2h46 chain E
2h5k chain A
2h5k chain B
2huw chain A
2huw chain B
2vvk chain A
2vwf chain A
2w0z chain A
3c7i chain A
3imd chain A
3imd chain B
3imj chain A
3imj chain B
3in7 chain A
3in7 chain C
3in8 chain A
3kfj chain A
3mxc chain A
3mxy chain A
3n7y chain A
3n7y chain B
3n7y chain C
3n84 chain A
3n84 chain B
3n84 chain C
3n84 chain D
3n84 chain E
3n84 chain F
3n8m chain A
3ov1 chain A
3ove chain A
3s8l chain A
3s8n chain A
3s8o chain A
3wa4 chain A
4p9v chain A
4p9z chain A
5cdw chain A
5cdw chain B
5cdw chain C
5cdw chain E
5cdw chain G
5cdw chain H
5cdw chain K
5cdw chain L
5cdw chain O
5cdw chain P
5cdw chain U
5cdw chain V
5cdw chain Y
5cdw chain Z
5cdw chain c
5cdw chain d
6icg chain A
6icg chain B
6ich chain A
6sdf chain A
6sdf chain B
6vk2 chain A
6wm1 chain A
6wm1 chain C
6wo2 chain A
6wo2 chain B
7mph chain A
7mph chain B
7mph chain C
7mph chain D
7mph chain E
7mph chain F
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S18 ATADDELS FKRGDIL 7 213 - - 26 22 - - 24 - 6 4 35 32 8 9 - - 5 1 34 7 S90 FLIRESES APGDFSL 9 812 55 - 48 39 - - 81 - 7 3 88 83 95 89 48 11 37 15 95 18 Y160 QVPQQPTY VQALFDF 1 8 - - - - - - - - - - - - 4 4 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S18 ATADDELS FKRGDIL -0.011 - -0.34 - - - -8.6e-3 - - - - S90 FLIRESES APGDFSL 2.5e-3 - 0.05 - - - -0.089 0.67 -0.28 3.6e-5 2.5e-4 Y160 QVPQQPTY VQALFDF - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S18
S90
Y160
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S18 S90 Y160 protein RNA SCNV methylation CCRCC S18 S90 Y160 protein RNA SCNV methylation COAD S18 S90 Y160 protein RNA SCNV methylation GBM S18 S90 Y160 protein RNA SCNV methylation HNSCC S18 S90 Y160 protein RNA SCNV methylation LSCC S18 S90 Y160 protein RNA SCNV methylation LUAD S18 S90 Y160 protein RNA SCNV methylation OV S18 S90 Y160 protein RNA SCNV methylation PDAC S18 S90 Y160 protein RNA SCNV methylation UCEC S18 S90 Y160 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S18
S90
Y160
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S18
S90
Y160
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.