TRIO: trio Rho guanine nucleotide exchange factor
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1nty chain A
2nz8 chain B
6d8z chain A
6d8z chain B
6d8z chain C
7sj4 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T517 DKLQRPLT PGSSDSL 1 8 - - - - - - - - - - 4 4 - - - - - - - - S520 QRPLTPGS SDSLTAS 3 44 - - - - - - 26 - - - 5 5 - - - - - - 5 3 S521 RPLTPGSS DSLTASA 1 9 - - - - - - 9 - - - - - - - - - - - - - S523 LTPGSSDS LTASANY 7 290 24 - 44 33 - - 9 - - - 33 30 30 28 - - 18 7 29 5 S527 SSDSLTAS ANYSKAV 1 18 - - - - - - - - - - - - 10 8 - - - - - - S1258 DSNKSSKS LQLDIIP 8 679 80 - 43 43 - - 37 - 85 49 54 49 93 85 - - 16 7 29 9 S1271 IPASIPGS EVKLRDA 1 8 - - 4 4 - - - - - - - - - - - - - - - - T1562 FALWVGRT PTSDNKI 1 62 - - - - - - 62 - - - - - - - - - - - - - S1627 RDGEDLDS QGDGSSQ 2 18 - - - - - - - - - - 5 4 5 4 - - - - - - S1632 LDSQGDGS SQPDTIS 2 14 - - 4 4 - - - - - - - - - - - - - - 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T517 DKLQRPLT PGSSDSL - - - - - - - - - - - S520 QRPLTPGS SDSLTAS - - - - - - - - - - - S521 RPLTPGSS DSLTASA - - - - - - - - - - - S523 LTPGSSDS LTASANY 2e-17 - 1.4e-7 - - - 7.8e-8 4.5e-5 - - - S527 SSDSLTAS ANYSKAV - - - - - - - - - - - S1258 DSNKSSKS LQLDIIP 8.9e-43 - 1.1e-9 - - 8.1e-9 4.7e-13 8.6e-17 - - - S1271 IPASIPGS EVKLRDA - - - - - - - - - - - T1562 FALWVGRT PTSDNKI - - - - - - - - - - - S1627 RDGEDLDS QGDGSSQ - - - - - - - - - - - S1632 LDSQGDGS SQPDTIS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T517
S520
S521
S523
S527
S1258
S1271
T1562
S1627
S1632
S1633
T1644
S1645
S1651
S1655
S1721
S1723
S1724
S1745
S1752
S1785
S1786
S1814
S1818
S1821
T1824
T1843
S1845
S1854
T1899
S1900
S1901
S1928
S1929
S1938
S1939
S1941
S1945
S1948
S1951
S1953
S1954
S2122
T2281
S2282
S2291
S2355
S2359
T2371
S2402
S2417
S2429
S2440
T2443
S2455
S2459
S2462
S2463
S2476
S2477
S2484
S2488
S2492
S2495
S2499
T2501
S2506
S2508
S2629
T2630
S2631
S2662
S2671
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation CCRCC T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation COAD T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation GBM T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation HNSCC T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation LSCC T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation LUAD T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation OV T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation PDAC T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation UCEC T517 S520 S521 S523 S527 S1258 S1271 T1562 S1627 S1632 S1633 T1644 S1645 S1651 S1655 S1721 S1723 S1724 S1745 S1752 S1785 S1786 S1814 S1818 S1821 T1824 T1843 S1845 S1854 T1899 S1900 S1901 S1928 S1929 S1938 S1939 S1941 S1945 S1948 S1951 S1953 S1954 S2122 T2281 S2282 S2291 S2355 S2359 T2371 S2402 S2417 S2429 S2440 T2443 S2455 S2459 S2462 S2463 S2476 S2477 S2484 S2488 S2492 S2495 S2499 T2501 S2506 S2508 S2629 T2630 S2631 S2662 S2671 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T517
S520
S521
S523
S527
S1258
S1271
T1562
S1627
S1632
S1633
T1644
S1645
S1651
S1655
S1721
S1723
S1724
S1745
S1752
S1785
S1786
S1814
S1818
S1821
T1824
T1843
S1845
S1854
T1899
S1900
S1901
S1928
S1929
S1938
S1939
S1941
S1945
S1948
S1951
S1953
S1954
S2122
T2281
S2282
S2291
S2355
S2359
T2371
S2402
S2417
S2429
S2440
T2443
S2455
S2459
S2462
S2463
S2476
S2477
S2484
S2488
S2492
S2495
S2499
T2501
S2506
S2508
S2629
T2630
S2631
S2662
S2671
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T517
S520
S521
S523
S527
S1258
S1271
T1562
S1627
S1632
S1633
T1644
S1645
S1651
S1655
S1721
S1723
S1724
S1745
S1752
S1785
S1786
S1814
S1818
S1821
T1824
T1843
S1845
S1854
T1899
S1900
S1901
S1928
S1929
S1938
S1939
S1941
S1945
S1948
S1951
S1953
S1954
S2122
T2281
S2282
S2291
S2355
S2359
T2371
S2402
S2417
S2429
S2440
T2443
S2455
S2459
S2462
S2463
S2476
S2477
S2484
S2488
S2492
S2495
S2499
T2501
S2506
S2508
S2629
T2630
S2631
S2662
S2671
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.