FERMT2: fermitin family member 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2lgx chain A
2lko chain A
2msu chain A
4f7h chain A
6u4n chain A
6xtj chain AAA
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S159 KKKLDDQS EDEALEL 10 1473 122 - 103 80 97 100 80 - 108 62 108 99 110 101 43 11 100 42 89 18 T172 ELEGPLIT PGSGSIY 8 124 6 - 11 11 1 7 7 - 6 4 10 9 23 20 - - 6 3 - - S175 GPLITPGS GSIYSSP 9 750 24 - 87 72 60 74 17 - 56 31 58 54 45 41 - - 61 23 42 5 S177 LITPGSGS IYSSPGL 9 368 9 - 36 34 53 53 9 - 36 19 5 5 9 8 - - 35 16 37 4 Y179 TPGSGSIY SSPGLYS 4 60 - - 4 4 - - - - - - 14 14 8 9 7 - - - - - S180 PGSGSIYS SPGLYSK 6 93 - - 12 11 15 12 - - 11 6 5 5 4 4 - - - - 5 3 S181 GSGSIYSS PGLYSKT 3 70 - - - - - - 42 - 11 7 5 5 - - - - - - - - Y185 IYSSPGLY SKTMTPT 1 10 - - - - - - - - - - 5 5 - - - - - - - - T188 SPGLYSKT MTPTYDA 2 17 - - - - - - 9 - - - - - - - - - - - 5 3 T190 GLYSKTMT PTYDAHD 6 195 - - - - 65 67 9 - 11 7 10 10 4 4 - - - - 5 3
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S159 KKKLDDQS EDEALEL -7.7e-77 - -1.6e-18 -1.1e-19 - -2e-19 -8.8e-35 -6e-36 -3.2e-8 1.5e-10 -0.097 T172 ELEGPLIT PGSGSIY -9.4e-9 - - - - - - -9.4e-9 - - - S175 GPLITPGS GSIYSSP -7.5e-39 - -6.4e-12 -6.8e-13 - -0.013 -3.7e-19 -6.1e-21 - 3.4e-3 - S177 LITPGSGS IYSSPGL -3.4e-9 - -2.1e-10 -2.6e-9 - -2.2e-3 - - - 3.9e-4 - Y179 TPGSGSIY SSPGLYS - - - - - - - - - - - S180 PGSGSIYS SPGLYSK - - - - - - - - - - - S181 GSGSIYSS PGLYSKT - - - - - - - - - - - Y185 IYSSPGLY SKTMTPT - - - - - - - - - - - T188 SPGLYSKT MTPTYDA - - - - - - - - - - - T190 GLYSKTMT PTYDAHD -1.7e-14 - - -1.7e-14 - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S159
T172
S175
S177
Y179
S180
S181
Y185
T188
T190
Y193
S199
S202
S205
S211
S214
S224
S229
S332
S339
S351
S363
T364
S371
Y378
S414
T416
S483
Y590
S610
S666
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation CCRCC S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation COAD S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation GBM S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation HNSCC S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation LSCC S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation LUAD S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation OV S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation PDAC S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation UCEC S159 T172 S175 S177 Y179 S180 S181 Y185 T188 T190 Y193 S199 S202 S205 S211 S214 S224 S229 S332 S339 S351 S363 T364 S371 Y378 S414 T416 S483 Y590 S610 S666 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S159
T172
S175
S177
Y179
S180
S181
Y185
T188
T190
Y193
S199
S202
S205
S211
S214
S224
S229
S332
S339
S351
S363
T364
S371
Y378
S414
T416
S483
Y590
S610
S666
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S159
T172
S175
S177
Y179
S180
S181
Y185
T188
T190
Y193
S199
S202
S205
S211
S214
S224
S229
S332
S339
S351
S363
T364
S371
Y378
S414
T416
S483
Y590
S610
S666
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.