PTPN11: protein tyrosine phosphatase non-receptor type 11
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2shp chain A
2shp chain B
3b7o chain A
3mow chain A
3o5x chain A
3tkz chain A
3tl0 chain A
3zm0 chain A
3zm1 chain A
3zm2 chain A
3zm3 chain A
4dgp chain A
4dgx chain A
4gwf chain A
4gwf chain B
4h1o chain A
4h34 chain A
4je4 chain A
4jeg chain A
4jmg chain B
4nwf chain A
4nwf chain B
4nwg chain A
4nwg chain B
4ohd chain A
4ohe chain A
4ohh chain A
4ohi chain A
4ohl chain A
4ohl chain B
4pvg chain A
4qsy chain A
4rdd chain A
5bk8 chain A
5df6 chain A
5ehp chain A
5ehp chain B
5ehr chain A
5ehr chain B
5i6v chain A
5i6v chain B
5ibm chain A
5ibm chain B
5ibs chain A
5ibs chain B
5x7b chain A
5x94 chain A
5x94 chain B
5xzr chain A
6atd chain A
6atd chain B
6bmr chain A
6bmr chain B
6bmu chain A
6bmu chain B
6bmv chain A
6bmv chain B
6bmw chain A
6bmw chain B
6bmx chain A
6bmx chain B
6bmy chain A
6bmy chain B
6bn5 chain A
6bn5 chain B
6cmp chain A
6cmp chain B
6cmq chain A
6cmq chain B
6cmq chain C
6cmq chain D
6cmr chain A
6cms chain A
6crf chain A
6crf chain B
6crg chain A
6crg chain B
6md7 chain A
6md7 chain B
6md9 chain A
6md9 chain B
6mda chain A
6mda chain B
6mdb chain A
6mdb chain B
6mdc chain A
6mdc chain B
6mdd chain A
6mdd chain B
6r5g chain A
6roy chain A
6roy chain B
6roz chain A
6roz chain C
6wu8 chain A
6wu8 chain B
7emn chain A
7emn chain B
7jvm chain A
7jvm chain B
7jvn chain A
7jvn chain B
7r75 chain A
7r7d chain A
7r7d chain B
7r7i chain A
7r7i chain B
7r7l chain A
7r7l chain B
7rct chain A
7rct chain B
7vxg chain A
7vxg chain B
7vxg chain C
7vxg chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S28 LTRGVDGS FLARPSK 1 9 - - - - - - 9 - - - - - - - - - - - - - S34 GSFLARPS KSNPGDF 5 239 23 - 73 52 - - 35 - - - - - 26 24 - - - - 6 - S36 FLARPSKS NPGDFTL 7 308 - - 13 12 - - 62 - 18 11 43 40 19 15 - - 8 4 45 18 Y62 KIQNTGDY YDLYGGE 10 1200 92 - 70 58 61 56 99 - 68 37 88 81 80 72 62 14 105 44 95 18 Y63 IQNTGDYY DLYGGEK 2 17 - - 4 4 - - - - - - - - 5 4 - - - - - - S134 TEKGKHGS FLVRESQ 1 9 - - - - - - 9 - - - - - - - - - - - - - S142 FLVRESQS HPGDFVL 2 71 - - - - - - 62 - - - - - 5 4 - - - - - - S189 GGGERFDS LTDLVEH 2 53 - - 4 4 - - 45 - - - - - - - - - - - - - T191 GERFDSLT DLVEHYK 2 15 7 - 4 4 - - - - - - - - - - - - - - - - Y542 SKRKGHEY TNIKYSL 10 1445 122 - 95 72 63 63 99 - 108 62 103 95 110 101 83 19 96 41 95 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S28 LTRGVDGS FLARPSK - - - - - - - - - - - S34 GSFLARPS KSNPGDF -1.6e-18 - -1.1e-9 - - - - -2.4e-10 - - - S36 FLARPSKS NPGDFTL -1.6e-12 - - - - - -4.9e-9 - - - -3.5e-5 Y62 KIQNTGDY YDLYGGE -1.1e-21 - -1.8e-6 -5.4e-3 - -8.1e-4 -1.7e-16 -0.07 0.92 -5.9e-5 -0.028 Y63 IQNTGDYY DLYGGEK - - - - - - - - - - - S134 TEKGKHGS FLVRESQ - - - - - - - - - - - S142 FLVRESQS HPGDFVL - - - - - - - - - - - S189 GGGERFDS LTDLVEH - - - - - - - - - - - T191 GERFDSLT DLVEHYK - - - - - - - - - - - Y542 SKRKGHEY TNIKYSL -8e-92 - -0.12 -7.4e-14 - -2.8e-25 -4.9e-33 -6.9e-32 -2.6e-9 -8.5e-4 -4.4e-7
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S28
S34
S36
Y62
Y63
S134
S142
S189
T191
Y542
T553
S554
S558
T564
T566
Y580
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation CCRCC S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation COAD S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation GBM S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation HNSCC S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation LSCC S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation LUAD S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation OV S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation PDAC S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation UCEC S28 S34 S36 Y62 Y63 S134 S142 S189 T191 Y542 T553 S554 S558 T564 T566 Y580 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S28
S34
S36
Y62
Y63
S134
S142
S189
T191
Y542
T553
S554
S558
T564
T566
Y580
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S28
S34
S36
Y62
Y63
S134
S142
S189
T191
Y542
T553
S554
S558
T564
T566
Y580
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.