RASAL3: RAS protein activator like 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S10 PPSPSRTS QTQPTAT 1 9 - - - - - - - - - - - - - - 7 2 - - - - T15 RTSQTQPT ATSPLTS 1 8 8 - - - - - - - - - - - - - - - - - - - T17 SQTQPTAT SPLTSYR 3 67 - - 17 8 - - - - - - - - 18 16 7 1 - - - - S18 QTQPTATS PLTSYRW 10 554 32 - 13 11 13 23 81 - 64 39 63 58 18 16 8 1 40 14 54 6 T27 LTSYRWHT GGGGEKA 5 230 7 - 37 20 - - - - - - 38 34 26 26 - - 28 14 - - S51 AGWGRALS HQEPMVS 10 1509 122 - 99 76 83 87 99 - 108 62 108 99 105 97 83 19 105 44 95 18 S72 SIFRRVLS APPKESR 10 1526 122 - 103 80 95 93 90 - 108 62 108 99 110 101 83 19 105 44 95 9 S164 PRRPRVGS ASSEGSI 9 181 9 - 4 4 - - 36 - 11 6 24 22 13 12 8 1 4 2 18 7 S166 RPRVGSAS SEGSIHV 9 466 56 - 26 16 16 10 9 - 4 4 83 77 67 60 15 3 13 7 - - S167 PRVGSASS EGSIHVA 10 401 56 - 30 20 16 10 36 - 9 8 83 77 4 4 8 1 9 5 18 7
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S10 PPSPSRTS QTQPTAT - - - - - - - - - - - T15 RTSQTQPT ATSPLTS - - - - - - - - - - - T17 SQTQPTAT SPLTSYR - - - - - - - - - - - S18 QTQPTATS PLTSYRW -0.068 - - - - 0.013 -3.4e-12 - - 0.18 - T27 LTSYRWHT GGGGEKA 0.44 - 3.9e-8 - - - -3.1e-4 0.78 - -0.52 - S51 AGWGRALS HQEPMVS 4.4e-6 - 1.7e-19 -0.1 - 9.4e-9 0.56 8.9e-4 0.51 -0.18 -7.5e-4 S72 SIFRRVLS APPKESR 0.47 - 8.4e-27 -0.76 - 2.9e-4 -2.3e-14 -2.2e-7 -1.4e-3 0.011 - S164 PRRPRVGS ASSEGSI -0.013 - - - - - -0.013 - - - - S166 RPRVGSAS SEGSIHV -0.065 - 4.0e-5 - - - -3.2e-6 -0.008 - - - S167 PRVGSASS EGSIHVA -0.67 - 5.0e-5 - - - -3.2e-6 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S10
T15
T17
S18
T27
S51
S72
S164
S166
S167
S170
S224
S228
S231
T234
S759
S760
S762
S785
S787
S790
S794
S796
S819
S831
S841
S843
S857
S859
S865
S944
S949
S988
T991
S994
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation CCRCC S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation COAD S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation GBM S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation HNSCC S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation LSCC S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation LUAD S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation OV S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation PDAC S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation UCEC S10 T15 T17 S18 T27 S51 S72 S164 S166 S167 S170 S224 S228 S231 T234 S759 S760 S762 S785 S787 S790 S794 S796 S819 S831 S841 S843 S857 S859 S865 S944 S949 S988 T991 S994 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S10
T15
T17
S18
T27
S51
S72
S164
S166
S167
S170
S224
S228
S231
T234
S759
S760
S762
S785
S787
S790
S794
S796
S819
S831
S841
S843
S857
S859
S865
S944
S949
S988
T991
S994
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S10
T15
T17
S18
T27
S51
S72
S164
S166
S167
S170
S224
S228
S231
T234
S759
S760
S762
S785
S787
S790
S794
S796
S819
S831
S841
S843
S857
S859
S865
S944
S949
S988
T991
S994
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.