USP7: ubiquitin specific peptidase 7
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1nb8 chain A
1nb8 chain B
1nbf chain A
1nbf chain B
1nbf chain E
1yy6 chain A
1yze chain A
1yze chain B
1yze chain C
2f1w chain A
2f1x chain A
2f1x chain B
2f1y chain A
2f1z chain A
2f1z chain B
2foj chain A
2foo chain A
2fop chain A
2kvr chain A
2xxn chain A
2ylm chain A
3mqr chain A
3mqs chain C
4jjq chain A
4kg9 chain A
4m5w chain A
4m5x chain A
4m5x chain B
4pyz chain A
4pyz chain B
4wph chain A
4wph chain B
4wpi chain A
4wpi chain B
4yoc chain C
4ysi chain A
4z96 chain A
4z97 chain A
5c56 chain A
5c6d chain A
5c6d chain B
5fwi chain C
5gg4 chain A
5gg4 chain B
5gg4 chain C
5gg4 chain D
5j7t chain A
5jtj chain A
5jtv chain A
5jtv chain C
5jtv chain E
5jtv chain G
5kyb chain A
5kyb chain B
5kyc chain B
5kyd chain A
5kye chain A
5kye chain B
5kyf chain B
5n9r chain A
5n9r chain B
5n9t chain A
5n9t chain B
5nge chain A
5nge chain B
5ngf chain A
5ngf chain B
5uqv chain A
5uqv chain B
5uqx chain A
5uqx chain B
5vs6 chain A
5vs6 chain B
5vsb chain A
5vsb chain B
5vsk chain A
5vsk chain B
5whc chain A
5whc chain B
6f5h chain A
6f5h chain B
6m1k chain A
6m1k chain B
6p5l chain A
6p5l chain B
6vn2 chain A
6vn2 chain B
6vn3 chain A
6vn3 chain B
6vn4 chain A
6vn4 chain B
6vn5 chain A
6vn5 chain B
6vn6 chain A
6vn6 chain B
7cm2 chain A
7cm2 chain B
7vij chain A
7xpy chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S18 KAGEQQLS EPEDMEM 10 1536 122 - 103 80 97 100 99 - 108 62 108 99 101 93 83 19 105 44 95 18 T30 MEMEAGDT DDPPRIT 3 35 9 - 9 8 - - - - - - 5 4 - - - - - - - - S49 INGNVALS DGHNTAE 10 413 52 - 9 7 6 3 35 - 96 55 49 42 17 16 11 1 5 1 5 3 T54 ALSDGHNT AEEDMED 9 425 16 - 11 11 6 3 99 - 68 42 49 45 24 20 4 1 - - 13 13 S82 VERFSRLS ESVLSPP 2 17 7 - - - - - - - - - 5 5 - - - - - - - - S155 KSFSRRIS HLFFHKE 7 476 61 - 69 59 - - 71 - 29 17 20 19 61 57 - - 9 4 - - T397 EKGVKFLT LPPVLHL 1 7 - - - - - - - - - - - - - - - - - - 5 2 S731 AGFIQDTS LILYEEV 1 13 13 - - - - - - - - - - - - - - - - - - - S752 RIQDYDVS LDKALDE 8 460 45 - 25 24 - - 62 - 28 18 59 56 35 32 - - 14 5 41 16 S963 DELLECLS PATSRTF 9 1051 122 - 67 63 21 15 90 - 108 62 102 94 84 76 - - 53 22 58 14
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S18 KAGEQQLS EPEDMEM 6.2e-7 - -2.9e-6 1.5e-3 - 8.4e-7 1.7e-7 1.6e-18 -0.004 -1.6e-5 1.2e-4 T30 MEMEAGDT DDPPRIT - - - - - - - - - - - S49 INGNVALS DGHNTAE -0.035 - - - - -0.02 -0.51 - - - - T54 ALSDGHNT AEEDMED -6.5e-4 - - - - -0.014 -0.92 -8.4e-4 - - - S82 VERFSRLS ESVLSPP - - - - - - - - - - - S155 KSFSRRIS HLFFHKE -1.7e-7 - -1.8e-16 - - 9.8e-3 -0.88 -3.2e-6 - - - T397 EKGVKFLT LPPVLHL - - - - - - - - - - - S731 AGFIQDTS LILYEEV - - - - - - - - - - - S752 RIQDYDVS LDKALDE -0.48 - 0.82 - - 7.2e-3 -7.3e-4 -2.4e-4 - - 0.011 S963 DELLECLS PATSRTF 0.96 - 0.95 -0.27 - -8.6e-4 2.4e-3 -0.92 - -0.38 0.014
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S18
T30
S49
T54
S82
S155
T397
S731
S752
S963
T966
S967
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation CCRCC S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation COAD S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation GBM S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation HNSCC S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation LSCC S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation LUAD S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation OV S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation PDAC S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation UCEC S18 T30 S49 T54 S82 S155 T397 S731 S752 S963 T966 S967 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S18
T30
S49
T54
S82
S155
T397
S731
S752
S963
T966
S967
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S18
T30
S49
T54
S82
S155
T397
S731
S752
S963
T966
S967
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.