Protein: ENSP00000343873

NNT:: nicotinamide nucleotide transhydrogenase

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
T216	NHFGRFFTGQITAAG	1	9	-	-	-	-	-	-	-	-	7	2	-	-	-	-	-	-	-	-	-	-
Y373	KGITHIGYTDLPSRM	1	31	-	-	16	15	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S769	KLQGLLKSAPLLLPG	1	19	-	-	-	-	-	-	19	-	-	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 3 of 3 rows

Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
T216	NHFGRFFTGQITAAG	-	-	-	-	-	-	-	-	-	-	-
Y373	KGITHIGYTDLPSRM	-	-	-	-	-	-	-	-	-	-	-
S769	KLQGLLKSAPLLLPG	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 3 of 3 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
HALLMARK_MYOGENESIS	S769	6.0e-4	-	-	-	6.0e-4	-	-	-	-	-	-
PERT-PSP_PHORBOL_ESTER	S769	1.1e-3	-	-	-	1.1e-3	-	-	-	-	-	-
PROGENy: TNFa	S769	1.2e-3	-	-	-	1.2e-3	-	-	-	-	-	-
HALLMARK_IL6_JAK_STAT3_SIGNALING	S769	1.2e-3	-	-	-	1.2e-3	-	-	-	-	-	-
HALLMARK_INFLAMMATORY_RESPONSE	S769	1.5e-3	-	-	-	1.5e-3	-	-	-	-	-	-
HALLMARK_ALLOGRAFT_REJECTION	S769	1.8e-3	-	-	-	1.8e-3	-	-	-	-	-	-
HALLMARK_COMPLEMENT	S769	1.9e-3	-	-	-	1.9e-3	-	-	-	-	-	-
PATH-NP_LEPTIN_PATHWAY	S769	2.1e-3	-	-	-	2.1e-3	-	-	-	-	-	-
HALLMARK_KRAS_SIGNALING_UP	S769	2.4e-3	-	-	-	2.4e-3	-	-	-	-	-	-
PROGENy: NFkB	S769	2.6e-3	-	-	-	2.6e-3	-	-	-	-	-	-

Showing 1 to 10 of 774 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
ADCK5	Y373	1.1e-3	-	1.1e-3	-	-	-	-	-	-	-	-
CDC42BPG	Y373	1.9e-3	-	1.9e-3	-	-	-	-	-	-	-	-
ADCK1	Y373	2.3e-3	-	2.3e-3	-	-	-	-	-	-	-	-
TP53RK	Y373	3.8e-3	-	3.8e-3	-	-	-	-	-	-	-	-
STK10	S769	3.9e-3	-	-	-	3.9e-3	-	-	-	-	-	-
ERBB2	Y373	0.006	-	0.006	-	-	-	-	-	-	-	-
COQ8B	Y373	6.5e-3	-	6.5e-3	-	-	-	-	-	-	-	-
CDK20	S769	7.3e-3	-	-	-	7.3e-3	-	-	-	-	-	-
SYK	S769	7.3e-3	-	-	-	7.3e-3	-	-	-	-	-	-
LRRK2	Y373	8.6e-3	-	8.6e-3	-	-	-	-	-	-	-	-

Showing 1 to 10 of 1614 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
CTDSPL2	S769	-3.7e-4	-	-	-	-3.7e-4	-	-	-	-	-	-
ILKAP	S769	-1.7e-3	-	-	-	-1.7e-3	-	-	-	-	-	-
PPM1G	S769	-2.3e-3	-	-	-	-2.3e-3	-	-	-	-	-	-
NT5DC2	S769	-0.013	-	-	-	-0.013	-	-	-	-	-	-
DUSP11	S769	-0.014	-	-	-	-0.014	-	-	-	-	-	-
PPP1CB	Y373	-0.02	-	-0.02	-	-	-	-	-	-	-	-
PPP4C	S769	-0.04	-	-	-	-0.04	-	-	-	-	-	-
PTPN2	S769	-0.049	-	-	-	-0.049	-	-	-	-	-	-
PTPRU	Y373	-0.058	-	-0.058	-	-	-	-	-	-	-	-
PGAM5	S769	-0.062	-	-	-	-0.062	-	-	-	-	-	-

Showing 1 to 10 of 720 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000343873Gene: NNT

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000343873
Gene: NNT