FGD6: FYVE, RhoGEF and PH domain containing 6
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T61 PKPKVLKT SPVREIG 2 17 - - - - - - 9 - - - 4 4 - - - - - - - - S62 KPKVLKTS PVREIGQ 9 793 78 - 45 33 - - 9 - 85 48 84 77 81 72 28 6 86 34 16 11 S70 PVREIGQS PSRKIML 8 297 9 - 4 4 - - - - 31 21 43 40 27 23 20 4 18 6 36 11 S107 NQSNDYIS PMCSCSS 2 25 8 - - - - - - - - - 9 8 - - - - - - - - S111 DYISPMCS CSSECIH 1 38 - - - - - - - - - - 20 18 - - - - - - - - S177 GGVVLKAS VLEEELK 1 8 - - 8 - - - - - - - - - - - - - - - - - S205 QKHRPTDS PEMNGGC 4 259 28 - - - - - - - - - 74 68 46 39 - - - - 4 - S226 RIEFADLS PSPSSFE 8 307 9 - 12 12 - - - - 20 8 24 23 70 64 5 - 18 4 34 4 S228 EFADLSPS PSSFEKV 6 247 8 - 13 4 - - - - - - 43 41 35 31 - - 13 6 35 18 S230 ADLSPSPS SFEKVPD 1 9 9 - - - - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T61 PKPKVLKT SPVREIG - - - - - - - - - - - S62 KPKVLKTS PVREIGQ 2.3e-54 - 6e-8 - - 4.1e-16 1.7e-16 6.4e-11 - 1.6e-10 - S70 PVREIGQS PSRKIML 1.6e-41 - - - - 1.7e-8 3.7e-20 5e-11 - - 2.2e-8 S107 NQSNDYIS PMCSCSS - - - - - - - - - - - S111 DYISPMCS CSSECIH -0.035 - - - - - -0.035 - - - - S177 GGVVLKAS VLEEELK - - - - - - - - - - - S205 QKHRPTDS PEMNGGC 1.2e-30 - - - - - 1.3e-12 4.3e-20 - - - S226 RIEFADLS PSPSSFE 1.1e-4 - - - - - 0.044 5.7e-4 - - - S228 EFADLSPS PSSFEKV 3.1e-8 - - - - - 0.05 1.1e-3 - - 1.3e-5 S230 ADLSPSPS SFEKVPD - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T61
S62
S70
S107
S111
S177
S205
S226
S228
S230
S231
S392
T408
T409
S410
S417
S454
S491
S503
S515
S552
S553
S554
S585
S605
S607
S651
S692
T693
Y696
S707
S721
S732
S739
S742
Y760
Y797
S1197
S1203
S1210
S1288
S1293
S1313
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation CCRCC T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation COAD T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation GBM T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation HNSCC T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation LSCC T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation LUAD T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation OV T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation PDAC T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation UCEC T61 S62 S70 S107 S111 S177 S205 S226 S228 S230 S231 S392 T408 T409 S410 S417 S454 S491 S503 S515 S552 S553 S554 S585 S605 S607 S651 S692 T693 Y696 S707 S721 S732 S739 S742 Y760 Y797 S1197 S1203 S1210 S1288 S1293 S1313 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T61
S62
S70
S107
S111
S177
S205
S226
S228
S230
S231
S392
T408
T409
S410
S417
S454
S491
S503
S515
S552
S553
S554
S585
S605
S607
S651
S692
T693
Y696
S707
S721
S732
S739
S742
Y760
Y797
S1197
S1203
S1210
S1288
S1293
S1313
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T61
S62
S70
S107
S111
S177
S205
S226
S228
S230
S231
S392
T408
T409
S410
S417
S454
S491
S503
S515
S552
S553
S554
S585
S605
S607
S651
S692
T693
Y696
S707
S721
S732
S739
S742
Y760
Y797
S1197
S1203
S1210
S1288
S1293
S1313
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.