Protein: ENSP00000345739
Gene: DNMT1

LinkedOmicsKB © 2022-2023 Zhang Lab

DNMT1:
DNA methyltransferase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S127VGMADANSPPKPLSK101309122-4031726399-1086210899110101401193379518
S141KPRTPRRSKSDGEAK95568-43325445-5498905852--1038118
S143RTPRRSKSDGEAKPE101347114-8261939599-1086293848781224105449518
S152GEAKPEPSPSPRITR714423-----9-211410101212195--72
S154AKPEPSPSPRITRKS101106122-2424756964-955693837871761661255816
T166RKSTRQTTITSHFAK18------------44------
S189EESERAKSDESIKEE6281--2120--54-445855----2162513
S192ERAKSDESIKEEDKD7306--2120--27-5631454044--2814124
T253RSQTKEPTPKQKLKE29772-------------187----
S312EKVNPQISDEKDEDE827937-168--27-3014292754--535618
Showing 1 to 10 of 21 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S127VGMADANSPPKPLSK1.1e-66-3.8e-38.1e-8-1.1e-161.2e-336.4e-240.0262.7e-80.023
S141KPRTPRRSKSDGEAK0.63--0.068---0.390.18--0.55
S143RTPRRSKSDGEAKPE3.3e-48-0.683.1e-18-2.5e-122.3e-173.5e-19-0.0254.9e-3
S152GEAKPEPSPSPRITR1.2e-5----1.2e-5-----
S154AKPEPSPSPRITRKS6.3e-68-8.8e-31.7e-15-2.8e-163.3e-301.2e-202.4e-60.182.2e-4
T166RKSTRQTTITSHFAK-----------
S189EESERAKSDESIKEE5.1e-13-0.39---4.5e-18---2.9e-3
S192ERAKSDESIKEEDKD3.8e-8-0.39--1.2e-54.1e-16---0.017-
T253RSQTKEPTPKQKLKE-----------
S312EKVNPQISDEKDEDE6.1e-15----1.2e-41.1e-7---1.3e-5
Showing 1 to 10 of 21 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationCCRCCS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationCOADS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationGBMS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationHNSCCS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationLSCCS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationLUADS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationOVS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationPDACS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylationUCECS127S141S143S152S154T166S189S192T253S312T328S394S398S714S732S954S1105S1447S1467S1468S1469proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.