MAGI2: membrane associated guanylate kinase, WW and PDZ domain containing 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1uep chain A
1ueq chain A
1uew chain A
1ujv chain A
1wfv chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S220 GKRKRNKS VSNMEKA 9 847 41 - 73 54 5 4 62 - 72 43 108 99 63 57 - - 69 32 51 14 T250 NGNGVVVT PESSEHE 2 86 - - 4 4 - - 78 - - - - - - - - - - - - - S253 GVVVTPES SEHEDKS 2 51 - - 17 16 - - 18 - - - - - - - - - - - - - S254 VVVTPESS EHEDKSA 2 61 - - 13 12 - - 36 - - - - - - - - - - - - - S260 SSEHEDKS AGASGEM 1 44 - - - - - - 44 - - - - - - - - - - - - - Y362 EKIDDPIY GTYYVDH 3 59 - - - - - - 35 - - - - - - - 12 5 - - 5 2 S622 FGFTIADS PTGQRVK 1 99 - - - - - - 99 - - - - - - - - - - - - - S686 IHRGGFFS PWKTPKP 2 104 14 - - - - - 90 - - - - - - - - - - - - - S727 PPALHRSS FPDSTEA 4 131 - - - - - - 80 - - - - - - - 21 5 5 1 19 - S769 RTSFRMDS SGPDYKE 1 81 - - - - - - 81 - - - - - - - - - - - - -
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S220 GKRKRNKS VSNMEKA -9.3e-68 - -4.1e-20 - - -2.2e-10 -4.2e-35 -1.2e-19 - -0.16 -2.3e-5 T250 NGNGVVVT PESSEHE - - - - - - - - - - - S253 GVVVTPES SEHEDKS - - - - - - - - - - - S254 VVVTPESS EHEDKSA - - - - - - - - - - - S260 SSEHEDKS AGASGEM - - - - - - - - - - - Y362 EKIDDPIY GTYYVDH - - - - - - - - - - - S622 FGFTIADS PTGQRVK - - - - - - - - - - - S686 IHRGGFFS PWKTPKP - - - - - - - - - - - S727 PPALHRSS FPDSTEA - - - - - - - - - - - S769 RTSFRMDS SGPDYKE - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S220
T250
S253
S254
S260
Y362
S622
S686
S727
S769
S875
S878
S884
S885
T894
S896
S906
S938
S944
S1014
S1017
S1020
S1021
S1025
S1031
S1037
T1046
S1049
S1126
S1301
S1317
S1319
S1345
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation CCRCC S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation COAD S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation GBM S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation HNSCC S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation LSCC S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation LUAD S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation OV S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation PDAC S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation UCEC S220 T250 S253 S254 S260 Y362 S622 S686 S727 S769 S875 S878 S884 S885 T894 S896 S906 S938 S944 S1014 S1017 S1020 S1021 S1025 S1031 S1037 T1046 S1049 S1126 S1301 S1317 S1319 S1345 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S220
T250
S253
S254
S260
Y362
S622
S686
S727
S769
S875
S878
S884
S885
T894
S896
S906
S938
S944
S1014
S1017
S1020
S1021
S1025
S1031
S1037
T1046
S1049
S1126
S1301
S1317
S1319
S1345
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S220
T250
S253
S254
S260
Y362
S622
S686
S727
S769
S875
S878
S884
S885
T894
S896
S906
S938
S944
S1014
S1017
S1020
S1021
S1025
S1031
S1037
T1046
S1049
S1126
S1301
S1317
S1319
S1345
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.