WNK3: WNK lysine deficient protein kinase 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5nkp chain C
5nkp chain D
5o1v chain A
5o1v chain B
5o21 chain A
5o21 chain B
5o23 chain A
5o23 chain B
5o26 chain A
5o26 chain B
5o2b chain A
5o2b chain B
5o2c chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S49 KNSTFSAS GETVERK 1 10 - - - - - - - - - - 5 5 - - - - - - - - S62 RKRFFRKS VEMTEDD 6 218 - - - - - - 99 - 6 4 20 18 - - 7 1 28 10 16 9 S75 DDKVAESS PKDERIK 1 54 - - - - - - 54 - - - - - - - - - - - - - S112 KYEQCSKS TSEISKD 2 26 - - - - - - 17 - - - 5 4 - - - - - - - - S682 VPQIKPVS QPVGAEQ 1 9 - - - - - - 9 - - - - - - - - - - - - - S701 LKPDLVRS LNQDVAT 2 31 - - - - - - 18 - - - - - - - - - - - 11 2 S734 RIKQRRAS CPRPEKG 7 198 39 - 3 3 - - 91 - - - - - 12 12 12 4 3 2 12 5 S886 IRNRETQS PPSLQHS 2 18 - - - - - - 9 - - - - - - - 8 1 - - - - S905 PGRHPLPS PKNTSNK 2 108 - - - - - - 73 - - - - - - - 28 7 - - - - S1028 PGESTQTS GNSLTTL 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S49 KNSTFSAS GETVERK - - - - - - - - - - - S62 RKRFFRKS VEMTEDD -0.25 - - - - - 0.03 - - -1.5e-4 - S75 DDKVAESS PKDERIK - - - - - - - - - - - S112 KYEQCSKS TSEISKD - - - - - - - - - - - S682 VPQIKPVS QPVGAEQ - - - - - - - - - - - S701 LKPDLVRS LNQDVAT - - - - - - - - - - - S734 RIKQRRAS CPRPEKG - - - - - - - - - - - S886 IRNRETQS PPSLQHS - - - - - - - - - - - S905 PGRHPLPS PKNTSNK - - - - - - - - - - - S1028 PGESTQTS GNSLTTL - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S49
S62
S75
S112
S682
S701
S734
S886
S905
S1028
S1070
T1090
T1091
S1095
S1171
S1329
S1331
S1395
S1471
S1473
S1585
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation CCRCC S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation COAD S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation GBM S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation HNSCC S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation LSCC S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation LUAD S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation OV S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation PDAC S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation UCEC S49 S62 S75 S112 S682 S701 S734 S886 S905 S1028 S1070 T1090 T1091 S1095 S1171 S1329 S1331 S1395 S1471 S1473 S1585 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S49
S62
S75
S112
S682
S701
S734
S886
S905
S1028
S1070
T1090
T1091
S1095
S1171
S1329
S1331
S1395
S1471
S1473
S1585
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S49
S62
S75
S112
S682
S701
S734
S886
S905
S1028
S1070
T1090
T1091
S1095
S1171
S1329
S1331
S1395
S1471
S1473
S1585
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.