FYN: FYN proto-oncogene, Src family tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1a0n chain B
1aot chain F
1aou chain F
1avz chain C
1azg chain B
1efn chain A
1efn chain C
1fyn chain A
1g83 chain A
1g83 chain B
1m27 chain C
1nyf chain A
1nyg chain A
1shf chain A
1shf chain B
1zbj chain A
2dq7 chain X
2mqi chain A
2mrj chain A
2mrk chain A
2mrk chain B
3h0f chain A
3h0h chain A
3h0i chain A
3h0i chain B
3ua6 chain A
3ua6 chain B
3ua7 chain A
3ua7 chain B
3ua7 chain C
3ua7 chain D
4d8d chain A
4d8d chain C
4eik chain A
4u17 chain A
4u17 chain B
4u17 chain C
4u1p chain A
4znx chain A
4znx chain B
4znx chain C
4znx chain D
5zau chain A
6edf chain A
6ipy chain A
6ipz chain Z
7a2j chain A
7a2j chain B
7a2k chain A
7a2k chain B
7a2k chain C
7a2k chain D
7a2l chain A
7a2l chain B
7a2m chain A
7a2m chain B
7a2n chain A
7a2n chain B
7a2n chain C
7a2n chain D
7a2o chain A
7a2p chain A
7a2q chain A
7a2r chain A
7a2s chain A
7a2t chain A
7a2u chain A
7a2v chain A
7a2w chain A
7a2x chain A
7a2y chain A
7a2z chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S21 LTEERDGS LNQSSGY 8 1006 - - 56 39 82 79 99 - 92 52 84 78 84 76 - - 72 27 77 9 S25 RDGSLNQS SGYRYGT 5 238 - - - - 4 5 81 - 5 4 68 63 - - - - - - 6 2 S26 DGSLNQSS GYRYGTD 7 228 - - 21 10 22 22 18 - 45 27 5 5 - - - - 29 10 14 - T35 YRYGTDPT PQHYPSF 1 9 - - - - - - 9 - - - - - - - - - - - - - S41 PTPQHYPS FGVTSIP 1 34 - - - - - - 34 - - - - - - - - - - - - - T62 AAGGQGLT VFGGVNS 1 9 - - - - - - 9 - - - - - - - - - - - - - T75 NSSSHTGT LRTRGGT 1 18 - - - - - - 18 - - - - - - - - - - - - - Y132 LTTGETGY IPSNYVA 1 9 - - - - - - 9 - - - - - - - - - - - - - Y150 SIQAEEWY FGKLGRK 1 9 - - - - - - 9 - - - - - - - - - - - - - S257 MPRLTDLS VKTKDVW 4 196 - - - - - - 63 - 6 4 - - - - 30 6 - - 72 15
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S21 LTEERDGS LNQSSGY 2.3e-9 - 1.5e-3 0.14 - 1.5e-5 3.8e-3 -0.22 - 6.7e-5 - S25 RDGSLNQS SGYRYGT -3.3e-19 - - - - - -3.3e-19 - - - - S26 DGSLNQSS GYRYGTD 0.53 - 4.2e-3 -1.8e-3 - 0.071 - - - -0.76 - T35 YRYGTDPT PQHYPSF - - - - - - - - - - - S41 PTPQHYPS FGVTSIP - - - - - - - - - - - T62 AAGGQGLT VFGGVNS - - - - - - - - - - - T75 NSSSHTGT LRTRGGT - - - - - - - - - - - Y132 LTTGETGY IPSNYVA - - - - - - - - - - - Y150 SIQAEEWY FGKLGRK - - - - - - - - - - - S257 MPRLTDLS VKTKDVW -0.67 - - - - - - - - - -0.67
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S21
S25
S26
T35
S41
T62
T75
Y132
Y150
S257
S393
Y531
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation CCRCC S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation COAD S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation GBM S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation HNSCC S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation LSCC S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation LUAD S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation OV S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation PDAC S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation UCEC S21 S25 S26 T35 S41 T62 T75 Y132 Y150 S257 S393 Y531 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S21
S25
S26
T35
S41
T62
T75
Y132
Y150
S257
S393
Y531
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S21
S25
S26
T35
S41
T62
T75
Y132
Y150
S257
S393
Y531
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.