PDLIM7: PDZ and LIM domain 7
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2q3g chain A
2q3g chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T34 PLSISRLT PGGKAAQ 1 6 - - - - - - - - - - - - - - - - - - 6 - S52 AVGDWVLS IDGENAG 2 17 - - 4 4 - - - - - - - - 5 4 - - - - - - S60 IDGENAGS LTHIEAQ 5 324 - - 9 8 - - - - 29 17 54 49 53 49 - - 40 16 - - S78 RACGERLS LGLSRAQ 3 46 - - - - - - - - - - 10 10 - - - - 5 2 17 2 S109 PRYTFAPS VSLNKTA 2 54 - - - - - - - - - - - - - - 7 1 - - 42 4 S111 YTFAPSVS LNKTARP 8 1132 - - 83 76 - - 99 - 98 56 88 82 101 93 76 18 105 44 95 18 S144 RPLVPDAS KQRLMEN 8 726 9 - 65 46 32 31 - - 6 4 64 58 101 93 - - 87 40 74 16 T152 KQRLMENT EDWRPRP 2 10 - - 4 4 - - - - - - - - - - 1 1 - - - - T161 DWRPRPGT GQSRSFR 7 573 - - 55 44 - - - - 46 27 30 29 67 59 1 1 99 40 66 9 S164 PRPGTGQS RSFRILA 5 45 - - 4 4 - - - - - - - - 5 4 1 1 14 4 5 3
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T34 PLSISRLT PGGKAAQ - - - - - - - - - - - S52 AVGDWVLS IDGENAG - - - - - - - - - - - S60 IDGENAGS LTHIEAQ -8.5e-6 - - - - -0.72 -2.1e-7 -4.7e-13 - 1.0e-4 - S78 RACGERLS LGLSRAQ - - - - - - - - - - - S109 PRYTFAPS VSLNKTA - - - - - - - - - - - S111 YTFAPSVS LNKTARP 0.1 - -5.3e-3 - - 2.6e-12 -6.0e-5 -0.58 -2.7e-4 1.4e-16 0.9 S144 RPLVPDAS KQRLMEN -1.5e-9 - -0.086 -4.2e-3 - - -5.3e-14 -1.4e-24 - 7.5e-9 0.079 T152 KQRLMENT EDWRPRP - - - - - - - - - - - T161 DWRPRPGT GQSRSFR 9.9e-18 - -0.91 - - 0.36 1.2e-4 1.3e-12 - 1e-13 - S164 PRPGTGQS RSFRILA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T34
S52
S60
S78
S109
S111
S144
T152
T161
S164
T174
T176
S191
S204
T205
T214
S217
T239
S240
S247
T251
T253
S257
T259
S260
S274
T279
S340
T372
S451
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation CCRCC T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation COAD T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation GBM T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation HNSCC T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation LSCC T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation LUAD T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation OV T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation PDAC T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation UCEC T34 S52 S60 S78 S109 S111 S144 T152 T161 S164 T174 T176 S191 S204 T205 T214 S217 T239 S240 S247 T251 T253 S257 T259 S260 S274 T279 S340 T372 S451 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T34
S52
S60
S78
S109
S111
S144
T152
T161
S164
T174
T176
S191
S204
T205
T214
S217
T239
S240
S247
T251
T253
S257
T259
S260
S274
T279
S340
T372
S451
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T34
S52
S60
S78
S109
S111
S144
T152
T161
S164
T174
T176
S191
S204
T205
T214
S217
T239
S240
S247
T251
T253
S257
T259
S260
S274
T279
S340
T372
S451
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.