PAK1: p21 (RAC1) activated kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1f3m chain A
1f3m chain B
1f3m chain C
1f3m chain D
1yhv chain A
1yhw chain A
1zsg chain B
2hy8 chain 1
2qme chain I
3dvp chain C
3dvp chain D
3fxz chain A
3fy0 chain A
3q4z chain A
3q4z chain B
3q52 chain A
3q53 chain A
4daw chain A
4eqc chain A
4o0r chain A
4o0r chain B
4o0t chain A
4o0t chain B
4p90 chain A
4p90 chain B
4zji chain A
4zji chain B
4zji chain C
4zji chain D
4zjj chain A
4zjj chain B
4zjj chain C
4zjj chain D
4zlo chain A
4zlo chain B
4zy4 chain A
4zy4 chain B
4zy5 chain A
4zy5 chain B
4zy6 chain A
4zy6 chain B
5dew chain A
5dew chain B
5dey chain A
5dey chain B
5dfp chain A
5ime chain A
5ime chain B
5kbq chain A
5kbq chain B
5kbr chain A
5kbr chain B
6b16 chain A
6b16 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S21 APPMRNTS TMIGAGS 4 110 - - - - - - 9 - - - 10 10 - - - - 4 1 72 4 T22 PPMRNTST MIGAGSK 1 6 - - - - - - - - - - - - - - - - - - 6 - S28 STMIGAGS KDAGTLN 2 40 31 - - - - - 9 - - - - - - - - - - - - - S38 AGTLNHGS KPLPPNP 1 8 - - - - - - - - - - - - - - - - - - 6 2 S57 KKDRFYRS ILPGDKT 5 91 - - 4 4 - - - - - - 24 21 4 4 - - 5 2 19 4 T113 LLQTSNIT KSEQKKN 3 26 8 - - - 7 2 - - - - 5 4 - - - - - - - - S115 QTSNITKS EQKKNPQ 7 350 48 - 4 4 19 17 - - - - 30 27 75 70 7 1 33 15 - - S139 NSKKTSNS QKYMSFT 2 56 - - - - 27 18 - - - - - - - - - - 6 5 - - S144 SNSQKYMS FTDKSAE 10 1539 122 - 96 73 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S149 YMSFTDKS AEDYNSS 7 312 16 - 32 31 - - 36 - 9 7 34 32 33 28 - - - - 47 7
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S21 APPMRNTS TMIGAGS - - - - - - - - - - - T22 PPMRNTST MIGAGSK - - - - - - - - - - - S28 STMIGAGS KDAGTLN - - - - - - - - - - - S38 AGTLNHGS KPLPPNP - - - - - - - - - - - S57 KKDRFYRS ILPGDKT 2.9e-4 - - - - - 2.9e-4 - - - - T113 LLQTSNIT KSEQKKN - - - - - - - - - - - S115 QTSNITKS EQKKNPQ 6.5e-25 - - - - - 4.8e-10 1e-12 - 6.6e-6 - S139 NSKKTSNS QKYMSFT 0.47 - - 0.47 - - - - - - - S144 SNSQKYMS FTDKSAE -0.28 - 3.7e-3 -5.7e-3 - 1.1e-4 -0.9 -0.16 -0.12 -0.46 -1.2e-3 S149 YMSFTDKS AEDYNSS 1.3e-4 - -3.2e-5 - - - 5.8e-6 4.5e-10 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S21
T22
S28
S38
S57
T113
S115
S139
S144
S149
S155
S156
S174
T185
S204
T212
T214
T219
S220
S223
T225
T229
T230
T236
S249
Y285
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation CCRCC S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation COAD S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation GBM S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation HNSCC S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation LSCC S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation LUAD S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation OV S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation PDAC S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation UCEC S21 T22 S28 S38 S57 T113 S115 S139 S144 S149 S155 S156 S174 T185 S204 T212 T214 T219 S220 S223 T225 T229 T230 T236 S249 Y285 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S21
T22
S28
S38
S57
T113
S115
S139
S144
S149
S155
S156
S174
T185
S204
T212
T214
T219
S220
S223
T225
T229
T230
T236
S249
Y285
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S21
T22
S28
S38
S57
T113
S115
S139
S144
S149
S155
S156
S174
T185
S204
T212
T214
T219
S220
S223
T225
T229
T230
T236
S249
Y285
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.