KDM1A: lysine demethylase 1A
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2com chain A
2dw4 chain A
2ejr chain A
2h94 chain A
2hko chain A
2iw5 chain A
2l3d chain A
2uxn chain A
2uxx chain A
2v1d chain A
2x0l chain A
2xaf chain A
2xag chain A
2xah chain A
2xaj chain A
2xaq chain A
2xas chain A
2y48 chain A
2z3y chain A
2z5u chain A
3abt chain A
3abu chain A
3zms chain A
3zmt chain A
3zmu chain A
3zmv chain A
3zmz chain A
3zn0 chain A
3zn1 chain A
4bay chain A
4czz chain A
4kum chain A
4uv8 chain A
4uv9 chain A
4uva chain A
4uvb chain A
4uvc chain A
4uxn chain A
4xbf chain A
5afw chain B
5h6q chain A
5h6r chain A
5it3 chain A
5it3 chain B
5l3b chain A
5l3c chain A
5l3d chain A
5l3e chain A
5l3f chain A
5l3g chain A
5lbq chain A
5lgn chain A
5lgt chain A
5lgu chain A
5lhg chain A
5lhh chain A
5lhi chain A
5x60 chain A
5yjb chain A
6e1f chain A
6e1f chain B
6e1f chain C
6e1f chain D
6k3e chain A
6kgk chain A
6kgl chain A
6kgm chain A
6kgn chain A
6kgo chain A
6kgp chain A
6kgq chain A
6kgr chain A
6nqm chain A
6nqu chain A
6nr5 chain A
6s35 chain A
6te1 chain A
6tuy chain A
6vyp chain K
6vyp chain M
6vyp chain k
6vyp chain m
6w4k chain A
6wc6 chain A
6wc6 chain C
7cdc chain A
7cdd chain A
7cde chain A
7cdf chain A
7cdg chain A
7e0g chain A
7jjl chain B
7jjm chain A
7jk7 chain A
7vqs chain A
7vqt chain A
7vqu chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S69 KKEPPRAS PPGGLAE 10 1444 113 - 103 80 57 59 99 - 108 62 108 99 110 101 67 16 105 44 95 18 S80 GLAEPPGS AGPQAGP 5 46 8 - - - - - - - 5 3 5 5 - - - - 7 3 10 - T88 AGPQAGPT VVPGSAT 6 208 6 - 24 22 - - - - - - 15 14 32 28 - - 5 1 52 9 T104 METGIAET PEGRRTS 7 327 14 - - - 21 15 25 - 49 24 37 33 14 12 - - - - 65 18 S126 EYREMDES LANLSED 2 17 - - - - - - - - - - - - - - 7 2 - - 5 3 S131 DESLANLS EDEYYSE 10 1395 122 - 103 80 56 43 99 - 102 59 108 97 106 96 52 10 105 44 95 18 Y135 ANLSEDEY YSEEERN 6 178 67 - 8 8 - - - - 7 2 29 26 5 4 - - 17 5 - - Y136 NLSEDEYY SEEERNA 9 206 43 - 20 17 5 4 - - 35 20 5 5 5 4 13 2 10 5 10 3 S137 LSEDEYYS EEERNAK 10 684 8 - 54 49 79 74 64 - 12 7 15 14 48 42 57 13 40 18 72 18 S166 PPEEENES EPEEPSG 10 1540 122 - 103 80 97 100 99 - 108 62 108 99 110 101 77 17 102 42 95 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S69 KKEPPRAS PPGGLAE 0.036 - -0.23 5.9e-3 - -0.09 6.1e-3 1.1e-6 -0.6 0.65 -0.14 S80 GLAEPPGS AGPQAGP - - - - - - - - - - - T88 AGPQAGPT VVPGSAT -0.93 - -0.13 - - - - 0.17 - - - T104 METGIAET PEGRRTS 0.12 - - -0.036 - 0.74 8.3e-4 - - - 0.13 S126 EYREMDES LANLSED - - - - - - - - - - - S131 DESLANLS EDEYYSE 2.3e-13 - -9.3e-14 2.3e-7 - 4.7e-7 9.9e-30 9e-25 -0.25 -6.6e-4 0.36 Y135 ANLSEDEY YSEEERN 7.3e-4 - - - - - 7.3e-4 - - - - Y136 NLSEDEYY SEEERNA -0.83 - -3.5e-6 - - 1.4e-5 - - - - - S137 LSEDEYYS EEERNAK 0.18 - -2.9e-3 0.17 - - - 4.2e-5 0.95 -7.3e-3 6.2e-4 S166 PPEEENES EPEEPSG 3.4e-26 - -3.1e-3 3.5e-7 - 2.4e-8 1.7e-18 4.6e-17 -7.3e-3 2e-10 0.17
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S69
S80
T88
T104
S126
S131
Y135
Y136
S137
S166
S172
S466
T841
S849
S851
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation CCRCC S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation COAD S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation GBM S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation HNSCC S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation LSCC S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation LUAD S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation OV S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation PDAC S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation UCEC S69 S80 T88 T104 S126 S131 Y135 Y136 S137 S166 S172 S466 T841 S849 S851 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S69
S80
T88
T104
S126
S131
Y135
Y136
S137
S166
S172
S466
T841
S849
S851
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S69
S80
T88
T104
S126
S131
Y135
Y136
S137
S166
S172
S466
T841
S849
S851
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.