SASH3: SAM and SH3 domain containing 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S7 _MLRRKPS NASEKEP 7 541 75 - - - 45 35 80 - - - 54 49 50 43 - - 60 26 10 14 S10 RRKPSNAS EKEPTQK 2 26 17 - - - - - - - - - - - 5 4 - - - - - - S21 PTQKKKLS LQRSSSF 1 23 - - - - - - 23 - - - - - - - - - - - - - S25 KKLSLQRS SSFKDFA 5 135 82 - - - 4 5 23 - - - - - - - 13 3 3 2 - - S26 KLSLQRSS SFKDFAK 2 17 8 - - - 4 5 - - - - - - - - - - - - - - S27 LSLQRSSS FKDFAKS 6 329 14 - - - 97 100 23 - - - - - 5 4 62 15 5 4 - - S34 SFKDFAKS KPSSPVV 7 249 8 - 4 4 - - 54 - - - 55 48 5 4 - - 32 12 18 5 S37 DFAKSKPS SPVVSEK 4 50 26 - - - 4 5 - - - - - - 5 4 - - 4 2 - - S38 FAKSKPSS PVVSEKE 10 1362 114 - 95 72 69 56 90 - 102 59 108 99 110 101 48 10 96 41 83 9 S42 KPSSPVVS EKEFNLD 10 664 58 - 8 8 10 8 90 - 101 59 29 27 78 73 6 2 47 21 32 7
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S7 _MLRRKPS NASEKEP 0.33 - - 9.0e-4 - - -0.054 0.52 - -0.93 - S10 RRKPSNAS EKEPTQK - - - - - - - - - - - S21 PTQKKKLS LQRSSSF - - - - - - - - - - - S25 KKLSLQRS SSFKDFA - - - - - - - - - - - S26 KLSLQRSS SFKDFAK - - - - - - - - - - - S27 LSLQRSSS FKDFAKS 7.4e-5 - - 0.13 - - - - 4.7e-5 - - S34 SFKDFAKS KPSSPVV -0.025 - - - - - -3.4e-5 - - 0.33 - S37 DFAKSKPS SPVVSEK - - - - - - - - - - - S38 FAKSKPSS PVVSEKE 2.7e-22 - 3e-20 1.7e-7 - 3.5e-9 -4.8e-4 0.034 0.19 6.4e-8 - S42 KPSSPVVS EKEFNLD 2e-13 - - - - 9e-12 -0.36 1.0e-5 - 1.2e-5 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S7
S10
S21
S25
S26
S27
S34
S37
S38
S42
S57
T83
S97
T103
S108
S110
T112
S113
Y116
S117
S120
S131
S142
S146
T147
S149
S155
S243
Y316
T318
S320
S349
S355
S357
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation CCRCC S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation COAD S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation GBM S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation HNSCC S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation LSCC S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation LUAD S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation OV S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation PDAC S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation UCEC S7 S10 S21 S25 S26 S27 S34 S37 S38 S42 S57 T83 S97 T103 S108 S110 T112 S113 Y116 S117 S120 S131 S142 S146 T147 S149 S155 S243 Y316 T318 S320 S349 S355 S357 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S7
S10
S21
S25
S26
S27
S34
S37
S38
S42
S57
T83
S97
T103
S108
S110
T112
S113
Y116
S117
S120
S131
S142
S146
T147
S149
S155
S243
Y316
T318
S320
S349
S355
S357
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S7
S10
S21
S25
S26
S27
S34
S37
S38
S42
S57
T83
S97
T103
S108
S110
T112
S113
Y116
S117
S120
S131
S142
S146
T147
S149
S155
S243
Y316
T318
S320
S349
S355
S357
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.