IGF2R: insulin like growth factor 2 receptor
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1e6f chain A
1e6f chain B
1gp0 chain A
1gp3 chain A
1gqb chain A
1gqb chain B
1jpl chain E
1jpl chain F
1jpl chain G
1jpl chain H
1jwg chain C
1jwg chain D
1lf8 chain E
1lf8 chain F
1lf8 chain G
1lf8 chain H
2cnj chain D
2l29 chain A
2l2a chain A
2m68 chain A
2m6t chain A
2v5n chain A
2v5o chain A
2v5p chain A
2v5p chain B
5iei chain A
6n5x chain A
6n5y chain A
6p8i chain A
6v02 chain A
6z30 chain A
6z31 chain A
6z31 chain B
6z32 chain A
6z32 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T296 PSERREGT IPKLTAK 1 6 - - - - - - - - - - - - - - - - - - 6 - S632 ENCTVFDS QAGFSFD 1 8 8 - - - - - - - - - - - - - - - - - - - T1367 ACPPFDLT ECSFKDG 1 9 - - - - - - 9 - - - - - - - - - - - - - S1370 PFDLTECS FKDGAGN 1 9 - - - - - - 9 - - - - - - - - - - - - - T1686 SEDDASDT NPDFYIN 1 6 - - 4 2 - - - - - - - - - - - - - - - - Y1691 SDTNPDFY INICQPL 1 8 - - 4 4 - - - - - - - - - - - - - - - - T1774 KRGVSMGT PKLLRTS 4 219 - - - - - - - - 75 41 20 19 - - - - 37 15 12 - S2346 LTTCCRRS SNVSYKY 1 8 - - - - - - - - - - 4 4 - - - - - - - - S2347 TTCCRRSS NVSYKYS 10 1359 65 - 70 59 90 89 99 - 108 62 84 76 110 101 83 19 105 44 79 16 S2350 CRRSSNVS YKYSKVN 6 77 - - 4 4 3 6 - - 23 12 5 4 - - - - 5 2 7 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T296 PSERREGT IPKLTAK - - - - - - - - - - - S632 ENCTVFDS QAGFSFD - - - - - - - - - - - T1367 ACPPFDLT ECSFKDG - - - - - - - - - - - S1370 PFDLTECS FKDGAGN - - - - - - - - - - - T1686 SEDDASDT NPDFYIN - - - - - - - - - - - Y1691 SDTNPDFY INICQPL - - - - - - - - - - - T1774 KRGVSMGT PKLLRTS 7.7e-16 - - - - 1.3e-10 4.6e-8 - - 0.038 - S2346 LTTCCRRS SNVSYKY - - - - - - - - - - - S2347 TTCCRRSS NVSYKYS 1e-21 - 0.19 2.9e-8 - 2.6e-13 2.6e-6 1.7e-8 1.7e-4 4.3e-3 -4.9e-5 S2350 CRRSSNVS YKYSKVN 8.5e-5 - - - - 8.5e-5 - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T296
S632
T1367
S1370
T1686
Y1691
T1774
S2346
S2347
S2350
Y2353
T2362
T2367
S2400
S2401
S2409
T2415
S2431
S2432
S2440
S2479
S2484
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation CCRCC T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation COAD T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation GBM T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation HNSCC T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation LSCC T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation LUAD T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation OV T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation PDAC T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation UCEC T296 S632 T1367 S1370 T1686 Y1691 T1774 S2346 S2347 S2350 Y2353 T2362 T2367 S2400 S2401 S2409 T2415 S2431 S2432 S2440 S2479 S2484 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T296
S632
T1367
S1370
T1686
Y1691
T1774
S2346
S2347
S2350
Y2353
T2362
T2367
S2400
S2401
S2409
T2415
S2431
S2432
S2440
S2479
S2484
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T296
S632
T1367
S1370
T1686
Y1691
T1774
S2346
S2347
S2350
Y2353
T2362
T2367
S2400
S2401
S2409
T2415
S2431
S2432
S2440
S2479
S2484
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.