RICTOR: RPTOR independent companion of MTOR complex 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5zcs chain E
5zcs chain F
6zwm chain E
6zwm chain F
6zwo chain F
7pe7 chain E
7pe7 chain F
7pe8 chain E
7pe9 chain E
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S21 RVRGRNDS GEENVPL 10 1455 96 - 103 80 81 80 81 - 108 62 108 99 110 101 67 17 105 44 95 18 S265 TDFHYRHS PDTAEGQ 9 410 32 - 32 28 4 5 44 - 46 25 34 33 47 43 - - 18 7 12 - T268 HYRHSPDT AEGQLKE 1 9 - - 5 4 - - - - - - - - - - - - - - - - S1016 EQLCNELS SIPSTLS 1 8 - - 4 4 - - - - - - - - - - - - - - - - S1020 NELSSIPS TLSLNSE 1 8 - - 4 4 - - - - - - - - - - - - - - - - S1023 SSIPSTLS LNSESTS 1 8 - - - - - - 8 - - - - - - - - - - - - - S1035 STSSRHNS ESESVPS 3 137 - - - - 5 4 - - - - - - 14 12 83 19 - - - - S1037 SSRHNSES ESVPSSM 1 8 - - - - - - - - - - - - - - 6 2 - - - - S1084 GPIKDKNS FPFFASS 7 199 30 - 13 12 - - - - 11 6 25 21 22 20 - - 14 6 17 2 S1090 NSFPFFAS SKLVKNR 1 6 - - - - - - - - - - - - - - - - - - 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S21 RVRGRNDS GEENVPL 0.035 - -6.5e-10 0.044 - 2.3e-9 -2.4e-3 0.38 -0.65 4.2e-11 0.88 S265 TDFHYRHS PDTAEGQ 3.3e-3 - 0.063 - - 0.1 0.94 0.022 - - - T268 HYRHSPDT AEGQLKE - - - - - - - - - - - S1016 EQLCNELS SIPSTLS - - - - - - - - - - - S1020 NELSSIPS TLSLNSE - - - - - - - - - - - S1023 SSIPSTLS LNSESTS - - - - - - - - - - - S1035 STSSRHNS ESESVPS 0.05 - - - - - - - 0.05 - - S1037 SSRHNSES ESVPSSM - - - - - - - - - - - S1084 GPIKDKNS FPFFASS 2.4e-12 - - - - - 3.4e-8 1.1e-5 - - - S1090 NSFPFFAS SKLVKNR - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S21
S265
T268
S1016
S1020
S1023
S1035
S1037
S1084
S1090
S1101
T1103
T1133
T1135
S1138
S1144
S1174
T1175
S1177
T1198
S1199
S1217
S1219
T1222
S1230
S1233
S1235
S1237
S1282
S1284
S1286
T1295
S1302
S1307
S1313
S1320
T1322
Y1330
T1332
S1346
S1353
S1370
T1376
S1385
Y1386
S1388
S1396
S1411
S1470
S1479
S1577
S1581
S1585
S1587
S1588
S1591
T1592
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation CCRCC S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation COAD S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation GBM S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation HNSCC S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation LSCC S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation LUAD S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation OV S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation PDAC S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation UCEC S21 S265 T268 S1016 S1020 S1023 S1035 S1037 S1084 S1090 S1101 T1103 T1133 T1135 S1138 S1144 S1174 T1175 S1177 T1198 S1199 S1217 S1219 T1222 S1230 S1233 S1235 S1237 S1282 S1284 S1286 T1295 S1302 S1307 S1313 S1320 T1322 Y1330 T1332 S1346 S1353 S1370 T1376 S1385 Y1386 S1388 S1396 S1411 S1470 S1479 S1577 S1581 S1585 S1587 S1588 S1591 T1592 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S21
S265
T268
S1016
S1020
S1023
S1035
S1037
S1084
S1090
S1101
T1103
T1133
T1135
S1138
S1144
S1174
T1175
S1177
T1198
S1199
S1217
S1219
T1222
S1230
S1233
S1235
S1237
S1282
S1284
S1286
T1295
S1302
S1307
S1313
S1320
T1322
Y1330
T1332
S1346
S1353
S1370
T1376
S1385
Y1386
S1388
S1396
S1411
S1470
S1479
S1577
S1581
S1585
S1587
S1588
S1591
T1592
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S21
S265
T268
S1016
S1020
S1023
S1035
S1037
S1084
S1090
S1101
T1103
T1133
T1135
S1138
S1144
S1174
T1175
S1177
T1198
S1199
S1217
S1219
T1222
S1230
S1233
S1235
S1237
S1282
S1284
S1286
T1295
S1302
S1307
S1313
S1320
T1322
Y1330
T1332
S1346
S1353
S1370
T1376
S1385
Y1386
S1388
S1396
S1411
S1470
S1479
S1577
S1581
S1585
S1587
S1588
S1591
T1592
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.