BRCA1: BRCA1 DNA repair associated
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1jm7 chain A
1jnx chain X
1n5o chain X
1oqa chain A
1t15 chain A
1t29 chain A
1t2u chain A
1t2v chain A
1t2v chain B
1t2v chain C
1t2v chain D
1t2v chain E
1y98 chain A
2ing chain X
3coj chain A
3coj chain B
3coj chain C
3coj chain D
3coj chain E
3coj chain F
3coj chain G
3coj chain X
3k0h chain A
3k0k chain A
3k15 chain A
3k16 chain A
3pxa chain A
3pxb chain A
3pxc chain X
3pxd chain A
3pxe chain A
3pxe chain B
3pxe chain C
3pxe chain D
4ifi chain A
4igk chain A
4igk chain B
4jlu chain A
4ofb chain A
4u4a chain A
4u4a chain B
4u4a chain C
4y18 chain A
4y18 chain B
4y18 chain C
4y18 chain D
4y18 chain E
4y18 chain F
4y18 chain G
4y18 chain H
4y2g chain A
6g2i chain H
6g2i chain K
6g2i chain M
6g2i chain O
6g2i chain S
6g2i chain U
6g2i chain W
6g2i chain Y
7jzv chain A
7lyb chain M
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S114 FAKKENNS PEHLKDE 7 1011 - - 71 54 - - 90 - 108 62 108 97 106 96 - - 85 35 83 16 T208 DQELLQIT PQGTRDE 1 9 - - - - - - - - - - 4 5 - - - - - - - - T333 ETCNDRRT PSTEKKV 1 6 - - - - - - - - - - - - - - - - - - 6 - S389 VNEWFSRS DELLGSD 2 18 - - - - - - 9 - - - - - - - - - - - - 9 S395 RSDELLGS DDSHDGE 7 422 - - 4 4 - - 18 - 84 47 78 72 20 16 - - 15 8 43 13 S398 ELLGSDDS HDGESES 7 114 - - 4 4 - - 18 - 18 10 15 15 5 4 - - 5 2 12 2 S403 DDSHDGES ESNAKVA 2 64 - - - - - - - - - - 29 28 - - - - - - 5 2 S423 LNEVDEYS GSSEKID 1 9 - - - - - - - - - - - - - - - - - - - 9 S425 EVDEYSGS SEKIDLL 2 28 - - - - - - 19 - - - 5 4 - - - - - - - - S426 VDEYSGSS EKIDLLA 1 6 - - - - - - - - - - - - - - - - - - 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S114 FAKKENNS PEHLKDE 4.7e-86 - 6.2e-14 - - 2.4e-16 2e-34 1.1e-31 - 1.1e-8 5.4e-3 T208 DQELLQIT PQGTRDE - - - - - - - - - - - T333 ETCNDRRT PSTEKKV - - - - - - - - - - - S389 VNEWFSRS DELLGSD - - - - - - - - - - - S395 RSDELLGS DDSHDGE 4e-34 - - - - 6.8e-8 9e-22 9.5e-7 - - 7.6e-6 S398 ELLGSDDS HDGESES - - - - - - - - - - - S403 DDSHDGES ESNAKVA 9.8e-13 - - - - - 9.8e-13 - - - - S423 LNEVDEYS GSSEKID - - - - - - - - - - - S425 EVDEYSGS SEKIDLL - - - - - - - - - - - S426 VDEYSGSS EKIDLLA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S114
T208
T333
S389
S395
S398
S403
S423
S425
S426
S434
T509
S551
S561
S632
S645
S844
T967
S1007
S1009
S1164
S1174
S1187
S1189
S1191
S1212
S1217
S1218
S1239
S1271
S1280
S1286
S1328
S1330
S1336
S1342
S1457
S1460
S1497
S1524
S1542
S1577
S1642
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation CCRCC S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation COAD S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation GBM S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation HNSCC S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation LSCC S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation LUAD S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation OV S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation PDAC S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation UCEC S114 T208 T333 S389 S395 S398 S403 S425 S426 S434 T509 S551 S561 S632 S645 S844 T967 S1007 S1009 S1164 S1174 S1187 S1189 S1191 S1212 S1217 S1218 S1239 S1280 S1286 S1328 S1330 S1336 S1342 S1457 S1460 S1497 S1524 S1542 S1577 S1642 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S114
T208
T333
S389
S395
S398
S403
S423
S425
S426
S434
T509
S551
S561
S632
S645
S844
T967
S1007
S1009
S1164
S1174
S1187
S1189
S1191
S1212
S1217
S1218
S1239
S1271
S1280
S1286
S1328
S1330
S1336
S1342
S1457
S1460
S1497
S1524
S1542
S1577
S1642
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S114
T208
T333
S389
S395
S398
S403
S423
S425
S426
S434
T509
S551
S561
S632
S645
S844
T967
S1007
S1009
S1164
S1174
S1187
S1189
S1191
S1212
S1217
S1218
S1239
S1271
S1280
S1286
S1328
S1330
S1336
S1342
S1457
S1460
S1497
S1524
S1542
S1577
S1642
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.