COPS5: COP9 signalosome subunit 5
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4d10 chain E
4d10 chain M
4d18 chain E
4d18 chain M
4f7o chain A
4f7o chain B
4wsn chain E
4wsn chain M
4wsn chain U
4wsn chain c
4wsn chain k
4wsn chain s
5jog chain A
5joh chain A
5m5q chain A
6r6h chain E
6r7f chain E
6r7h chain E
6r7i chain E
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S24 NNMQEAQS IDEIYKY 8 528 62 - 37 26 - - 90 - 67 37 39 36 62 58 - - 4 1 7 2 S284 EAQLGRGS FMLGLET 9 1087 46 - 79 66 13 14 99 - 103 59 98 91 106 97 55 12 105 44 - - S296 LETHDRKS EDKLAKA 1 8 - - 4 4 - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S24 NNMQEAQS IDEIYKY -7e-21 - -1.7e-4 - - -2.4e-9 -1.1e-4 -2.5e-7 - - - S284 EAQLGRGS FMLGLET -1.8e-44 - -2.1e-3 - - -0.016 -2.5e-23 -2.5e-28 -0.24 -4.2e-11 - S296 LETHDRKS EDKLAKA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S24
S284
S296
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S24 S284 S296 protein RNA SCNV methylation CCRCC S24 S284 S296 protein RNA SCNV methylation COAD S24 S284 S296 protein RNA SCNV methylation GBM S24 S284 S296 protein RNA SCNV methylation HNSCC S24 S284 S296 protein RNA SCNV methylation LSCC S24 S284 S296 protein RNA SCNV methylation LUAD S24 S284 S296 protein RNA SCNV methylation OV S24 S284 S296 protein RNA SCNV methylation PDAC S24 S284 S296 protein RNA SCNV methylation UCEC S24 S284 S296 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S24
S284
S296
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S24
S284
S296
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.