DMTN: dematin actin binding protein
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1qzp chain A
1zv6 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T10 RLQKQPLT SPGSVSP 3 34 - - 10 8 - - 9 - - - - - - - - - - - 5 2 S11 LQKQPLTS PGSVSPS 8 275 17 - 10 8 4 5 90 - 17 10 25 25 19 15 - - - - 28 2 S14 QPLTSPGS VSPSRDS 2 56 - - - - - - - - - - - - 17 16 - - - - 19 4 S16 LTSPGSVS PSRDSSV 10 1329 82 - 103 80 57 42 99 - 108 62 104 95 106 96 63 13 79 33 89 18 S18 SPGSVSPS RDSSVPG 3 80 - - 21 20 - - 9 - - - - - - - - - - - 19 11 S21 SVSPSRDS SVPGSPS 8 129 31 - 8 8 - - 9 - 11 6 4 4 18 16 - - 5 2 7 - S22 VSPSRDSS VPGSPSS 7 216 - - 34 23 20 16 18 - 4 4 - - 5 4 - - 8 4 61 15 S26 RDSSVPGS PSSIVAK 10 1424 104 - 91 76 71 63 99 - 102 58 108 99 110 101 77 17 105 44 83 16 S28 SSVPGSPS SIVAKMD 3 24 - - 5 4 - - - - - - - - 5 4 - - - - 6 - S29 SVPGSPSS IVAKMDN 3 87 - - - - - - - - - - 19 17 22 20 - - - - - 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T10 RLQKQPLT SPGSVSP - - - - - - - - - - - S11 LQKQPLTS PGSVSPS -2.6e-7 - - - - - -2.6e-7 - - - - S14 QPLTSPGS VSPSRDS - - - - - - - - - - - S16 LTSPGSVS PSRDSSV -1.2e-22 - 0.27 -0.026 - -6.6e-10 -3.4e-24 -6.7e-26 -1.1e-4 0.76 1.1e-4 S18 SPGSVSPS RDSSVPG 0.54 - 0.54 - - - - - - - - S21 SVSPSRDS SVPGSPS - - - - - - - - - - - S22 VSPSRDSS VPGSPSS -0.11 - -0.83 -3.5e-3 - - - - - - 0.7 S26 RDSSVPGS PSSIVAK -2.3e-56 - -0.27 -1.3e-6 - -2.1e-19 -3.9e-32 -1.9e-22 -3.2e-8 -0.21 -0.15 S28 SSVPGSPS SIVAKMD - - - - - - - - - - - S29 SVPGSPSS IVAKMDN -1.5e-9 - - - - - - -1.5e-9 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T10
S11
S14
S16
S18
S21
S22
S26
S28
S29
S85
S87
S90
T91
S92
S96
S103
S105
S110
S113
S124
S152
S156
S226
S246
S269
T274
T278
S279
S285
S287
S288
S289
T297
S299
S303
T304
S309
S311
S315
S333
S372
S383
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation CCRCC T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation COAD T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation GBM T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation HNSCC T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation LSCC T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation LUAD T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation OV T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation PDAC T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation UCEC T10 S11 S14 S16 S18 S21 S22 S26 S28 S29 S85 S87 S90 T91 S92 S96 S103 S105 S110 S113 S124 S152 S156 S226 S246 S269 T274 T278 S279 S285 S287 S288 S289 T297 S299 S303 T304 S309 S311 S315 S333 S372 S383 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T10
S11
S14
S16
S18
S21
S22
S26
S28
S29
S85
S87
S90
T91
S92
S96
S103
S105
S110
S113
S124
S152
S156
S226
S246
S269
T274
T278
S279
S285
S287
S288
S289
T297
S299
S303
T304
S309
S311
S315
S333
S372
S383
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T10
S11
S14
S16
S18
S21
S22
S26
S28
S29
S85
S87
S90
T91
S92
S96
S103
S105
S110
S113
S124
S152
S156
S226
S246
S269
T274
T278
S279
S285
S287
S288
S289
T297
S299
S303
T304
S309
S311
S315
S333
S372
S383
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.