PPIP5K2: diphosphoinositol pentakisphosphate kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3t54 chain A
3t7a chain A
3t99 chain A
3t9a chain A
3t9b chain A
3t9c chain A
3t9d chain A
3t9e chain A
3t9f chain A
4hn2 chain A
4nzm chain A
4nzn chain A
4nzo chain A
4q4c chain A
4q4d chain A
5bya chain A
5byb chain A
5dgh chain A
5dgi chain A
6n5c chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S38 DDEEEDDS PPERQIV 7 1024 - - 103 80 - - 90 - 93 51 108 99 106 98 - - 105 44 33 14 S275 DGKVERDS EGKEVRY 2 32 - - - - - - - - - - - - - - - - 8 3 21 - T491 LPHGCPKT SSEEEDS 5 63 - - 8 - - - 9 - 6 4 15 13 4 4 - - - - - - S492 PHGCPKTS SEEEDSR 7 424 - - 99 76 - - 9 - 77 47 19 17 27 24 - - 10 3 13 3 S493 HGCPKTSS EEEDSRR 7 678 - - 49 39 - - 27 - 43 21 93 86 88 81 - - 94 39 18 - S498 TSSEEEDS RREEPSL 1 8 - - 4 4 - - - - - - - - - - - - - - - - S504 DSRREEPS LLLVLKW 1 8 - - 4 4 - - - - - - - - - - - - - - - - T634 LQKDRDFT AEDYEKL 1 9 - - - - - - 9 - - - - - - - - - - - - - Y638 RDFTAEDY EKLTPSG 1 9 - - - - - - 9 - - - - - - - - - - - - - Y806 VNKLHPVY SRGVLSP 1 16 - - 8 8 - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S38 DDEEEDDS PPERQIV -0.55 - 6.4e-7 - - 0.19 0.23 0.014 - -2.8e-10 -0.03 S275 DGKVERDS EGKEVRY - - - - - - - - - - - T491 LPHGCPKT SSEEEDS - - - - - - - - - - - S492 PHGCPKTS SEEEDSR 0.22 - 0.22 - - -0.25 - 0.042 - - - S493 HGCPKTSS EEEDSRR 6.6e-4 - -3.1e-9 - - -0.027 3.1e-6 1.9e-11 - 1.2e-5 - S498 TSSEEEDS RREEPSL - - - - - - - - - - - S504 DSRREEPS LLLVLKW - - - - - - - - - - - T634 LQKDRDFT AEDYEKL - - - - - - - - - - - Y638 RDFTAEDY EKLTPSG - - - - - - - - - - - Y806 VNKLHPVY SRGVLSP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S38
S275
T491
S492
S493
S498
S504
T634
Y638
Y806
S916
S982
S983
S1006
T1011
S1012
S1013
S1016
S1029
S1067
S1073
S1074
S1091
S1108
S1110
T1161
S1165
T1167
S1171
S1172
S1180
T1192
T1219
S1220
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation CCRCC S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation COAD S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation GBM S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation HNSCC S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation LSCC S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation LUAD S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation OV S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation PDAC S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation UCEC S38 S275 T491 S492 S493 S498 S504 T634 Y638 Y806 S916 S982 S1006 T1011 S1012 S1013 S1016 S1029 S1067 S1073 S1074 S1091 S1108 S1110 T1161 S1165 T1167 S1171 S1172 S1180 T1192 T1219 S1220 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S38
S275
T491
S492
S493
S498
S504
T634
Y638
Y806
S916
S982
S983
S1006
T1011
S1012
S1013
S1016
S1029
S1067
S1073
S1074
S1091
S1108
S1110
T1161
S1165
T1167
S1171
S1172
S1180
T1192
T1219
S1220
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S38
S275
T491
S492
S493
S498
S504
T634
Y638
Y806
S916
S982
S983
S1006
T1011
S1012
S1013
S1016
S1029
S1067
S1073
S1074
S1091
S1108
S1110
T1161
S1165
T1167
S1171
S1172
S1180
T1192
T1219
S1220
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.