MAP3K5: mitogen-activated protein kinase kinase kinase 5
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2clq chain A
2clq chain B
3vw6 chain A
3vw6 chain B
4bf2 chain A
4bf2 chain B
4bhn chain A
4bhn chain B
4bib chain A
4bib chain B
4bic chain A
4bic chain B
4bid chain A
4bid chain B
4bie chain A
4bie chain B
5ulm chain A
5ulm chain B
5uor chain A
5uor chain B
5uox chain A
5uox chain B
5up3 chain A
5up3 chain B
5v19 chain A
5v19 chain B
5v24 chain A
5v24 chain B
5vil chain A
5vil chain B
5vil chain C
5vil chain D
5vio chain A
5vio chain B
5vio chain C
5vio chain D
6e2m chain A
6e2m chain B
6e2n chain A
6e2n chain B
6e2o chain A
6e2o chain B
6ejl chain C
6ejl chain D
6oyt chain A
6oyt chain B
6oyt chain C
6oyt chain D
6oyw chain A
6oyw chain B
6oyw chain C
6oyw chain D
6vre chain A
6vre chain B
6xih chain A
6xih chain B
7mu7 chain A
7mu7 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S82 SATRGRGS SVGGGSR 8 525 - - 12 12 28 34 71 - - - 44 39 47 43 31 9 62 28 56 9 S83 ATRGRGSS VGGGSRR 7 492 - - 12 12 - - 80 - - - 74 68 68 60 23 3 54 22 5 11 S101 AYVINEAS QGQLVVA 3 104 - - 4 4 - - - - - - 24 22 27 23 - - - - - - T838 GINPCTET FTGTLQY 1 72 - - - - 33 39 - - - - - - - - - - - - - - T840 NPCTETFT GTLQYMA 1 9 - - - - 7 2 - - - - - - - - - - - - - - S952 KKTQPKLS ALSAGSN 3 72 - - - - - - 27 - - - - - 17 16 - - - - 12 - S955 QPKLSALS AGSNEYL 3 36 - - 5 4 - - - - - - 10 8 - - - - - - - 9 S958 LSALSAGS NEYLRSI 10 1294 113 - 94 72 24 29 99 - 101 59 108 99 79 73 69 16 103 43 95 18 S964 GSNEYLRS ISLPVPV 1 9 - - - - - - 9 - - - - - - - - - - - - - S966 NEYLRSIS LPVPVLV 9 729 9 - 42 32 16 20 27 - 84 49 83 75 110 101 - - 30 12 23 16
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S82 SATRGRGS SVGGGSR 0.084 - - 0.58 - - 0.082 0.88 - 0.31 - S83 ATRGRGSS VGGGSRR -0.006 - - - - - -6.8e-4 -0.59 - -0.41 - S101 AYVINEAS QGQLVVA -6.0e-4 - - - - - -0.073 -2.2e-3 - - - T838 GINPCTET FTGTLQY 0.19 - - 0.19 - - - - - - - T840 NPCTETFT GTLQYMA - - - - - - - - - - - S952 KKTQPKLS ALSAGSN - - - - - - - - - - - S955 QPKLSALS AGSNEYL - - - - - - - - - - - S958 LSALSAGS NEYLRSI 9.8e-28 - -0.86 1.6e-3 - 7.8e-19 3.1e-15 3.8e-6 -0.92 1.7e-12 -0.66 S964 GSNEYLRS ISLPVPV - - - - - - - - - - - S966 NEYLRSIS LPVPVLV 3.6e-10 - 4.2e-3 - - 8.3e-3 2.8e-4 1.8e-6 - 0.28 0.72
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S82
S83
S101
T838
T840
S952
S955
S958
S964
S966
T976
Y982
S984
S986
S997
S1004
S1029
S1033
S1039
T1059
S1072
S1231
S1240
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation CCRCC S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation COAD S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation GBM S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation HNSCC S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation LSCC S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation LUAD S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation OV S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation PDAC S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation UCEC S82 S83 S101 T838 T840 S952 S955 S958 S964 S966 T976 Y982 S984 S986 S997 S1004 S1029 S1033 S1039 T1059 S1072 S1231 S1240 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S82
S83
S101
T838
T840
S952
S955
S958
S964
S966
T976
Y982
S984
S986
S997
S1004
S1029
S1033
S1039
T1059
S1072
S1231
S1240
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S82
S83
S101
T838
T840
S952
S955
S958
S964
S966
T976
Y982
S984
S986
S997
S1004
S1029
S1033
S1039
T1059
S1072
S1231
S1240
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.