PDE3A: phosphodiesterase 3A
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
7eg0 chain A
7eg0 chain C
7eg1 chain A
7eg1 chain C
7eg4 chain A
7eg4 chain C
7kwe chain A
7kwe chain B
7kwe chain C
7kwe chain D
7l27 chain A
7l27 chain B
7l27 chain C
7l27 chain D
7l28 chain A
7l28 chain B
7l28 chain C
7l28 chain D
7l29 chain A
7l29 chain B
7l29 chain C
7l29 chain D
7lrc chain B
7lrc chain C
7lrd chain B
7lrd chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S292 VFKRRRRS SSVVSAE 7 95 - - 4 4 21 15 9 - - - 5 4 5 4 - - 9 3 12 - S293 FKRRRRSS SVVSAEM 10 361 27 - 20 17 54 53 9 - 5 3 24 23 13 12 7 2 33 17 35 7 S294 KRRRRSSS VVSAEMS 10 352 9 - 21 12 47 51 27 - 6 4 30 27 18 15 7 2 7 4 58 7 S312 SKSHRRTS LPCIPRE 10 1504 122 - 86 73 97 100 99 - 93 52 108 99 110 101 83 19 105 44 95 18 S402 VNPVTSLS ENYTCSD 1 9 - - - - 4 5 - - - - - - - - - - - - - - T406 TSLSENYT CSDSEES 5 83 25 - 17 15 - - - - - - 5 5 - - 8 1 - - 5 2 S408 LSENYTCS DSEESSE 10 955 23 - 33 22 97 100 99 - 81 48 50 44 43 40 27 6 96 39 89 18 S428 IPKRLRRS LPPGLLR 7 556 - - 50 38 - - 26 - 34 20 68 64 44 40 83 19 - - 66 4 S438 PGLLRRVS STWTTTT 10 744 8 - 13 12 62 64 82 - 49 26 29 27 49 45 56 12 77 34 90 9 S439 GLLRRVSS TWTTTTS 5 49 - - 4 4 4 5 - - - - 5 5 - - 7 1 - - 14 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S292 VFKRRRRS SSVVSAE -5.3e-3 - - -5.3e-3 - - - - - - - S293 FKRRRRSS SVVSAEM -7e-14 - -0.11 -3.1e-15 - - -0.22 - - -1.9e-5 - S294 KRRRRSSS VVSAEMS -4.3e-5 - -0.84 -1.3e-10 - - -0.65 - - - - S312 SKSHRRTS LPCIPRE -5.8e-47 - -5.9e-8 -1.9e-30 - -0.45 -8.1e-27 -2.5e-14 -0.47 -1.8e-10 0.017 S402 VNPVTSLS ENYTCSD - - - - - - - - - - - T406 TSLSENYT CSDSEES - - - - - - - - - - - S408 LSENYTCS DSEESSE -9.1e-47 - 0.22 -2.6e-25 - -5.8e-15 -1.2e-12 -8.2e-8 - -5e-13 -0.19 S428 IPKRLRRS LPPGLLR -1.6e-31 - -0.94 - - -1.7e-12 -1.7e-20 -4.3e-8 -2.3e-5 - - S438 PGLLRRVS STWTTTT -2.3e-6 - - -9.1e-12 - -0.68 -5.3e-4 -6.7e-6 0.063 0.077 - S439 GLLRRVSS TWTTTTS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S292
S293
S294
S312
S402
T406
S408
S428
S438
S439
T440
T442
T443
S446
S463
S465
S478
S490
S492
T494
S496
Y497
S520
S523
S524
S527
S528
S543
S570
S575
T580
T611
T618
Y625
T627
S631
S633
S634
S654
S657
Y659
T663
S1030
S1033
T1036
T1054
T1107
S1112
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation CCRCC S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation COAD S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation GBM S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation HNSCC S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation LSCC S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation LUAD S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation OV S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation PDAC S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation UCEC S292 S293 S294 S312 S402 T406 S408 S428 S438 S439 T440 T442 T443 S446 S463 S465 S478 S490 S492 T494 S496 Y497 S520 S523 S524 S527 S528 S543 S570 S575 T580 T611 T618 Y625 T627 S631 S633 S634 S654 S657 Y659 T663 S1030 S1033 T1036 T1054 T1107 S1112 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S292
S293
S294
S312
S402
T406
S408
S428
S438
S439
T440
T442
T443
S446
S463
S465
S478
S490
S492
T494
S496
Y497
S520
S523
S524
S527
S528
S543
S570
S575
T580
T611
T618
Y625
T627
S631
S633
S634
S654
S657
Y659
T663
S1030
S1033
T1036
T1054
T1107
S1112
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S292
S293
S294
S312
S402
T406
S408
S428
S438
S439
T440
T442
T443
S446
S463
S465
S478
S490
S492
T494
S496
Y497
S520
S523
S524
S527
S528
S543
S570
S575
T580
T611
T618
Y625
T627
S631
S633
S634
S654
S657
Y659
T663
S1030
S1033
T1036
T1054
T1107
S1112
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.