Protein: ENSP00000353089
Gene: SRSF2

LinkedOmicsKB © 2022-2023 Zhang Lab

SRSF2:
serine and arginine rich splicing factor 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y23LKVDNLTYRTSPDTL322--8-----------8132--
T25VDNLTYRTSPDTLRR91031106-6055--90-854898913431831985339518
S26DNLTYRTSPDTLRRV9102261-1614--99-97566561110100831990389518
T29TYRTSPDTLRRVFEK37930-2119----------72----
S98RYGRPPDSHHSRRGP39449---------1512108------
S101RPPDSHHSRRGPPPR5315------99-5230----1347130511
S145SRSRSRYSRSKSRSR396--88--71-----54------
S147SRSRYSRSKSRSRTR395--88--71-----44------
S187RSRSRSRSRSRSPPP81177104-10380--99-9656103949789--105448918
S189RSRSRSRSRSPPPVS8468--2220--18-115108110101367529518
Showing 1 to 10 of 16 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y23LKVDNLTYRTSPDTL-----------
T25VDNLTYRTSPDTLRR3.8e-38-1.4e-9--1.4e-73.5e-250.0121.4e-72.7e-10-0.11
S26DNLTYRTSPDTLRRV2.3e-39----6.9e-173e-81.1e-190.144.2e-90.067
T29TYRTSPDTLRRVFEK-0.33--0.33--------
S98RYGRPPDSHHSRRGP-----------
S101RPPDSHHSRRGPPPR-0.026----0.17----5.7e-6-
S145SRSRSRYSRSKSRSR-----------
S147SRSRYSRSKSRSRTR-----------
S187RSRSRSRSRSRSPPP6e-23--3.2e-12--1.4e-51.8e-201.2e-16-5.0e-48.5e-9
S189RSRSRSRSRSPPPVS1.6e-11--5.1e-5----2.3e-21--4.8e-10
Showing 1 to 10 of 16 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationCCRCCY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationCOADY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationGBMY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationHNSCCY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationLSCCY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationLUADY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationOVY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationPDACY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylationUCECY23T25S26T29S98S101S145S147S187S189S191S206S208S212S220S221proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.