CACNA1A: calcium voltage-gated channel subunit alpha1 A
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3bxk chain B
3bxk chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T409 VILAEDET DGEQRHP 1 45 - - - - - - 45 - - - - - - - - - - - - - S450 ADIASVGS PFARASI 1 9 - - - - - - 9 - - - - - - - - - - - - - S465 KSAKLENS TFFHKKE 1 18 - - - - - - 18 - - - - - - - - - - - - - S749 AKEVAEVS PLSAANM 2 35 - - - - - - 27 - - - - - 4 4 - - - - - - S752 VAEVSPLS AANMSIA 2 17 - - - - - - 9 - - - - - 4 4 - - - - - - S757 PLSAANMS IAVKEQQ 2 17 - - - - - - 9 - - - - - 4 4 - - - - - - S789 RKQNLLAS REALYNE 1 98 - - - - - - 98 - - - - - - - - - - - - - S886 ARRPWAGS QEAELSR 1 45 - - - - - - 45 - - - - - - - - - - - - - S909 DHHAREGS LEQPGFW 1 37 - - - - - - 37 - - - - - - - - - - - - - S1093 GHAGLPQS PAKMGNS 1 81 - - - - - - 81 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T409 VILAEDET DGEQRHP - - - - - - - - - - - S450 ADIASVGS PFARASI - - - - - - - - - - - S465 KSAKLENS TFFHKKE - - - - - - - - - - - S749 AKEVAEVS PLSAANM - - - - - - - - - - - S752 VAEVSPLS AANMSIA - - - - - - - - - - - S757 PLSAANMS IAVKEQQ - - - - - - - - - - - S789 RKQNLLAS REALYNE - - - - - - - - - - - S886 ARRPWAGS QEAELSR - - - - - - - - - - - S909 DHHAREGS LEQPGFW - - - - - - - - - - - S1093 GHAGLPQS PAKMGNS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T409
S450
S465
S749
S752
S757
S789
S886
S909
S1093
T1983
S1994
T1996
S2008
S2027
S2029
T2042
S2119
S2126
S2139
S2246
S2248
S2250
S2266
S2268
T2278
T2292
S2300
S2377
S2379
S2423
S2444
S2451
S2464
S2499
S2501
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation CCRCC T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation COAD T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation GBM T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation HNSCC T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation LSCC T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation LUAD T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation OV T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation PDAC T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation UCEC T409 S450 S465 S749 S752 S757 S789 S886 S909 S1093 T1983 S1994 T1996 S2008 S2027 S2029 T2042 S2119 S2126 S2139 S2246 S2248 S2250 S2266 S2268 T2278 T2292 S2300 S2377 S2379 S2423 S2444 S2451 S2464 S2499 S2501 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T409
S450
S465
S749
S752
S757
S789
S886
S909
S1093
T1983
S1994
T1996
S2008
S2027
S2029
T2042
S2119
S2126
S2139
S2246
S2248
S2250
S2266
S2268
T2278
T2292
S2300
S2377
S2379
S2423
S2444
S2451
S2464
S2499
S2501
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T409
S450
S465
S749
S752
S757
S789
S886
S909
S1093
T1983
S1994
T1996
S2008
S2027
S2029
T2042
S2119
S2126
S2139
S2246
S2248
S2250
S2266
S2268
T2278
T2292
S2300
S2377
S2379
S2423
S2444
S2451
S2464
S2499
S2501
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.