UBA3: ubiquitin like modifier activating enzyme 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1r4m chain B
1r4m chain D
1r4m chain F
1r4m chain H
1r4n chain B
1r4n chain D
1r4n chain F
1r4n chain H
1tt5 chain B
1tt5 chain D
1y8x chain B
1yov chain B
1yov chain D
2lq7 chain A
2nvu chain B
3dbh chain B
3dbh chain D
3dbh chain F
3dbh chain H
3dbl chain B
3dbl chain D
3dbl chain F
3dbl chain H
3dbr chain B
3dbr chain D
3dbr chain F
3dbr chain H
3fn1 chain A
3gzn chain B
3gzn chain D
5jjm chain G
5jjm chain H
5jjm chain I
5jjm chain J
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S377 LPQNIQFS PSAKLQE 9 1099 105 - 94 72 2 7 81 - 108 62 73 66 105 97 - - 95 40 76 16 S399 SASLQMKS PAITATL 3 68 - - - - - - - - 7 3 - - 9 8 - - - - 35 6 T451 LAVADVTT PQTVLFK 1 8 - - - - - - - - 5 3 - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S377 LPQNIQFS PSAKLQE 3.4e-9 - -6.2e-3 - - 0.44 3.7e-13 2.6e-10 - -0.45 2.8e-4 S399 SASLQMKS PAITATL - - - - - - - - - - - T451 LAVADVTT PQTVLFK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S377
S399
T451
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S377 S399 T451 protein RNA SCNV methylation CCRCC S377 S399 T451 protein RNA SCNV methylation COAD S377 S399 T451 protein RNA SCNV methylation GBM S377 S399 T451 protein RNA SCNV methylation HNSCC S377 S399 T451 protein RNA SCNV methylation LSCC S377 S399 T451 protein RNA SCNV methylation LUAD S377 S399 T451 protein RNA SCNV methylation OV S377 S399 T451 protein RNA SCNV methylation PDAC S377 S399 T451 protein RNA SCNV methylation UCEC S377 S399 T451 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S377
S399
T451
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S377
S399
T451
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.