MAP3K3: mitogen-activated protein kinase kinase kinase 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2c60 chain A
2jrh chain A
2o2v chain B
2pph chain A
4y5o chain B
4yl6 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S110 AIDILDRS SSMKSLR 1 9 - - - - - - - - - - 5 4 - - - - - - - - S130 QDRNHNSS SPHSGVS 2 16 9 - - - - - - - 5 2 - - - - - - - - - - S131 DRNHNSSS PHSGVSR 7 222 8 - - - 44 38 28 - 16 7 - - 5 4 52 11 - - - 9 S145 RQVRIKAS QSAGDIN 6 293 - - - - 30 33 89 - 9 7 - - - - 16 2 56 25 17 9 S147 VRIKASQS AGDINTI 6 115 - - - - 9 9 9 - 7 3 - - - - 15 2 8 3 43 7 T153 QSAGDINT IYQPPEP 1 8 - - - - - - - - - - - - 4 4 - - - - - - S166 EPRSRHLS VSSQNPG 10 1230 85 - 55 41 59 66 78 - 108 62 103 95 97 89 72 14 80 34 76 16 S168 RSRHLSVS SQNPGRS 9 328 29 - 36 18 7 11 9 - 19 8 35 33 50 46 - - 13 8 6 - S169 SRHLSVSS QNPGRSS 9 328 38 - 36 18 4 5 9 - 19 8 35 33 50 46 - - 13 8 6 - S175 SSQNPGRS SPPPGYV 6 72 - - - - - - 8 - 6 3 - - 13 12 7 2 6 3 12 -
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S110 AIDILDRS SSMKSLR - - - - - - - - - - - S130 QDRNHNSS SPHSGVS - - - - - - - - - - - S131 DRNHNSSS PHSGVSR 0.016 - - 0.081 - - - - 0.098 - - S145 RQVRIKAS QSAGDIN -6.8e-4 - - -2.1e-3 - - - - - -0.083 - S147 VRIKASQS AGDINTI - - - - - - - - - - - T153 QSAGDINT IYQPPEP - - - - - - - - - - - S166 EPRSRHLS VSSQNPG -0.44 - 1.5e-4 -0.14 - 0.01 -3e-14 -0.41 -0.065 1.7e-5 -0.28 S168 RSRHLSVS SQNPGRS -9.3e-7 - 1.9e-3 - - - -2.8e-12 -3.9e-6 - - - S169 SRHLSVSS QNPGRSS -9.3e-7 - 1.9e-3 - - - -2.8e-12 -3.9e-6 - - - S175 SSQNPGRS SPPPGYV - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S110
S130
S131
S145
S147
T153
S166
S168
S169
S175
S176
S234
S237
S239
S250
S282
T294
S311
S312
S314
S316
T317
Y328
S337
S340
S355
S520
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation CCRCC S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation COAD S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation GBM S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation HNSCC S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation LSCC S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation LUAD S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation OV S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation PDAC S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation UCEC S110 S130 S131 S145 S147 T153 S166 S168 S169 S175 S176 S234 S237 S239 S250 S282 T294 S311 S312 S314 S316 T317 Y328 S337 S340 S355 S520 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S110
S130
S131
S145
S147
T153
S166
S168
S169
S175
S176
S234
S237
S239
S250
S282
T294
S311
S312
S314
S316
T317
Y328
S337
S340
S355
S520
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S110
S130
S131
S145
S147
T153
S166
S168
S169
S175
S176
S234
S237
S239
S250
S282
T294
S311
S312
S314
S316
T317
Y328
S337
S340
S355
S520
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.