Protein: ENSP00000354522

TOP1:: DNA topoisomerase I

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S97	KEEKVRASGDAKIKK	3	76	6	-	-	-	-	-	-	-	-	-	33	29	-	-	7	1	-	-	-	-
S111	KEKENGFSSPPQIKD	2	26	7	-	-	-	-	-	-	-	12	7	-	-	-	-	-	-	-	-	-	-
S112	EKENGFSSPPQIKDE	9	1006	46	-	90	68	-	-	99	-	103	58	68	63	67	60	46	13	100	43	64	18
Y125	DEPEDDGYFVPPKED	4	199	66	-	27	19	-	-	-	-	-	-	15	14	30	28	-	-	-	-	-	-
S394	SKDAKVPSPPPGHKW	10	1084	105	-	12	12	93	95	54	-	62	36	103	94	106	98	47	13	57	23	63	11

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Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S97	KEEKVRASGDAKIKK	1.2e-7	-	-	-	-	-	1.2e-7	-	-	-	-
S111	KEKENGFSSPPQIKD	-	-	-	-	-	-	-	-	-	-	-
S112	EKENGFSSPPQIKDE	-4.4e-10	-	1.5e-3	-	-	-1.2e-7	-6.1e-7	-9.7e-3	0.45	-1.8e-11	-0.4
Y125	DEPEDDGYFVPPKED	0.23	-	0.033	-	-	-	-	-0.66	-	-	-
S394	SKDAKVPSPPPGHKW	1.8e-47	-	-	2e-27	-	1.2e-11	4.3e-29	2.9e-3	0.21	0.024	2.9e-3

Showing 1 to 5 of 5 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000354522Gene: TOP1

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000354522
Gene: TOP1