ARHGEF11: Rho guanine nucleotide exchange factor 11
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1htj chain F
1xcg chain A
1xcg chain E
2dls chain A
3kz1 chain A
3kz1 chain B
3t06 chain A
3t06 chain E
5e6p chain B
5jhg chain A
5jhg chain E
5jhh chain A
5jhh chain E
5tyt chain A
5tyt chain B
5tyt chain C
5tyt chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S8 MSVRLPQS IDRLSSL 1 9 - - - - - - 9 - - - - - - - - - - - - - S14 QSIDRLSS LSSLGDS 9 781 55 - 18 15 5 4 90 - 26 18 78 72 79 72 - - 100 43 88 18 S16 IDRLSSLS SLGDSAP 7 244 52 - 17 15 - - - - 5 3 9 8 54 48 - - 14 7 12 - S17 DRLSSLSS LGDSAPE 8 296 24 - 17 15 - - 9 - 5 3 20 17 54 48 - - 9 4 56 15 S21 SLSSLGDS APERKSP 3 22 - - 4 4 - - 9 - - - - - - - - - 3 2 - - S27 DSAPERKS PSHHRQP 1 54 - - - - - - 54 - - - - - - - - - - - - - S35 PSHHRQPS DASETTG 9 1407 113 - 99 76 97 100 90 - 96 56 108 99 110 101 - - 105 44 95 18 S38 HRQPSDAS ETTGLVQ 1 24 - - - - - - - - - - - - - - - - - - 24 - S150 RITSVIPS PPPPPPL 9 1144 113 - 91 68 46 44 90 - 108 62 98 90 102 92 - - 19 8 95 18 S208 GDTSQRPS EGRLSLD 2 17 9 - 4 4 - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S8 MSVRLPQS IDRLSSL - - - - - - - - - - - S14 QSIDRLSS LSSLGDS 0.31 - - - - -0.7 -1.7e-3 1.4e-4 - 0.15 0.58 S16 IDRLSSLS SLGDSAP 2.1e-10 - - - - - - 2.1e-10 - - - S17 DRLSSLSS LGDSAPE 2.4e-9 - - - - - 0.94 2.1e-10 - - 9.3e-5 S21 SLSSLGDS APERKSP - - - - - - - - - - - S27 DSAPERKS PSHHRQP - - - - - - - - - - - S35 PSHHRQPS DASETTG -0.27 - 4.7e-4 -2.1e-13 - 0.81 -9.4e-3 0.55 - 2.1e-7 -0.012 S38 HRQPSDAS ETTGLVQ - - - - - - - - - - - S150 RITSVIPS PPPPPPL -0.19 - 7.7e-5 0.78 - -2.1e-8 -1.8e-5 -0.12 - - 5.8e-5 S208 GDTSQRPS EGRLSLD - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S8
S14
S16
S17
S21
S27
S35
S38
S150
S208
S213
S216
S221
S225
S232
S245
S251
T254
S255
S271
S286
S493
S545
S547
S556
Y578
T585
S589
T590
S592
S612
S614
S635
S651
S653
S654
S655
S658
S663
T668
T672
S679
S682
S684
S705
S851
S1155
S1168
S1170
T1292
S1295
S1300
S1313
S1411
S1413
S1452
S1457
S1458
T1461
T1462
S1466
S1478
S1480
S1494
S1505
S1512
S1519
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation CCRCC S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation COAD S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation GBM S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation HNSCC S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation LSCC S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation LUAD S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation OV S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation PDAC S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation UCEC S8 S14 S16 S17 S21 S27 S35 S38 S150 S208 S213 S216 S221 S225 S232 S245 S251 T254 S255 S271 S286 S493 S545 S547 S556 Y578 T585 S589 T590 S592 S612 S614 S635 S651 S653 S654 S655 S658 S663 T668 T672 S679 S682 S684 S705 S851 S1155 S1168 S1170 T1292 S1295 S1300 S1313 S1411 S1413 S1452 S1457 S1458 T1461 T1462 S1466 S1478 S1480 S1494 S1505 S1512 S1519 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S8
S14
S16
S17
S21
S27
S35
S38
S150
S208
S213
S216
S221
S225
S232
S245
S251
T254
S255
S271
S286
S493
S545
S547
S556
Y578
T585
S589
T590
S592
S612
S614
S635
S651
S653
S654
S655
S658
S663
T668
T672
S679
S682
S684
S705
S851
S1155
S1168
S1170
T1292
S1295
S1300
S1313
S1411
S1413
S1452
S1457
S1458
T1461
T1462
S1466
S1478
S1480
S1494
S1505
S1512
S1519
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S8
S14
S16
S17
S21
S27
S35
S38
S150
S208
S213
S216
S221
S225
S232
S245
S251
T254
S255
S271
S286
S493
S545
S547
S556
Y578
T585
S589
T590
S592
S612
S614
S635
S651
S653
S654
S655
S658
S663
T668
T672
S679
S682
S684
S705
S851
S1155
S1168
S1170
T1292
S1295
S1300
S1313
S1411
S1413
S1452
S1457
S1458
T1461
T1462
S1466
S1478
S1480
S1494
S1505
S1512
S1519
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.