MAST2: microtubule associated serine/threonine kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2kqf chain A
2kyl chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S29 VQRAAELS QSLPPRR 1 6 - - - - - - - - - - - - - - - - - - 6 - S66 QDVVTGVS PLLFRKL 10 1048 95 - 86 64 34 38 99 - 80 46 69 63 93 84 54 12 21 9 83 18 S74 PLLFRKLS NPDIFSS 9 757 23 - - - 90 90 90 - 45 27 15 15 15 12 72 14 96 40 95 18 S80 LSNPDIFS STGKVKL 4 70 33 - 4 4 - - - - - - 10 10 5 4 - - - - - - S81 SNPDIFSS TGKVKLQ 8 202 33 - 4 4 4 5 45 - - - 10 10 4 4 - - 9 3 58 9 S92 VKLQRQLS QDDCKLW 10 1249 65 - 46 43 92 96 90 - 108 62 84 76 81 74 70 15 99 41 89 18 S105 LWRGNLAS SLSGKQL 4 48 6 - - - - - - - - - 14 14 - - - - 7 2 5 - S106 WRGNLASS LSGKQLL 2 28 - - - - - - - - - - - - - - 7 1 - - 17 3 S108 GNLASSLS GKQLLPL 8 239 26 - 5 4 - - 28 - 12 6 15 13 4 5 - - 46 20 42 13 S144 LVRMRNQS LGQSAPS 5 48 6 - 4 4 - - 9 - - - - - 10 8 - - 5 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S29 VQRAAELS QSLPPRR - - - - - - - - - - - S66 QDVVTGVS PLLFRKL 0.38 - 6.6e-11 -0.01 - -1.6e-4 -0.43 0.69 0.2 - 0.21 S74 PLLFRKLS NPDIFSS 3e-12 - - 3.8e-3 - 1.3e-3 - - 1.5e-5 2e-13 -0.031 S80 LSNPDIFS STGKVKL - - - - - - - - - - - S81 SNPDIFSS TGKVKLQ - - - - - - - - - - - S92 VKLQRQLS QDDCKLW 0.34 - -0.066 0.21 - 3.2e-7 -0.059 0.39 -0.024 7.5e-13 -1e-8 S105 LWRGNLAS SLSGKQL - - - - - - - - - - - S106 WRGNLASS LSGKQLL - - - - - - - - - - - S108 GNLASSLS GKQLLPL -4.9e-3 - - - - - - - - -0.58 -6.0e-4 S144 LVRMRNQS LGQSAPS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S29
S66
S74
S80
S81
S92
S105
S106
S108
S144
S148
S151
S175
T182
S183
T185
S191
T197
S200
S204
S209
S278
T279
S281
S290
S299
S301
S305
S308
S311
S825
S855
S860
T867
S874
S876
S895
S900
S909
S911
T916
S931
S996
S1007
S1032
S1035
T1036
S1089
S1091
S1240
S1256
S1257
S1260
S1264
S1275
S1337
T1349
S1364
S1381
S1407
S1429
S1447
S1503
S1504
T1508
S1515
S1522
S1554
S1585
T1634
S1642
S1644
S1660
S1698
S1717
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation CCRCC S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation COAD S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation GBM S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation HNSCC S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation LSCC S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation LUAD S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation OV S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation PDAC S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation UCEC S29 S66 S74 S80 S81 S92 S105 S106 S108 S144 S148 S151 S175 T182 S183 T185 S191 T197 S200 S204 S209 S278 T279 S281 S290 S299 S301 S305 S308 S311 S825 S855 S860 T867 S874 S876 S895 S900 S909 S911 T916 S931 S996 S1007 S1032 S1035 T1036 S1089 S1091 S1240 S1256 S1257 S1260 S1264 S1275 S1337 T1349 S1364 S1381 S1407 S1429 S1503 S1504 T1508 S1515 S1522 S1554 S1585 T1634 S1642 S1644 S1660 S1698 S1717 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S29
S66
S74
S80
S81
S92
S105
S106
S108
S144
S148
S151
S175
T182
S183
T185
S191
T197
S200
S204
S209
S278
T279
S281
S290
S299
S301
S305
S308
S311
S825
S855
S860
T867
S874
S876
S895
S900
S909
S911
T916
S931
S996
S1007
S1032
S1035
T1036
S1089
S1091
S1240
S1256
S1257
S1260
S1264
S1275
S1337
T1349
S1364
S1381
S1407
S1429
S1447
S1503
S1504
T1508
S1515
S1522
S1554
S1585
T1634
S1642
S1644
S1660
S1698
S1717
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S29
S66
S74
S80
S81
S92
S105
S106
S108
S144
S148
S151
S175
T182
S183
T185
S191
T197
S200
S204
S209
S278
T279
S281
S290
S299
S301
S305
S308
S311
S825
S855
S860
T867
S874
S876
S895
S900
S909
S911
T916
S931
S996
S1007
S1032
S1035
T1036
S1089
S1091
S1240
S1256
S1257
S1260
S1264
S1275
S1337
T1349
S1364
S1381
S1407
S1429
S1447
S1503
S1504
T1508
S1515
S1522
S1554
S1585
T1634
S1642
S1644
S1660
S1698
S1717
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.