ARHGEF2: Rho/Rac guanine nucleotide exchange factor 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S109 NTALQSVS LRSKTTI 9 580 81 - 59 46 - - 19 - 35 20 83 77 27 24 14 2 19 8 50 16 S121 TTIRERPS SAIYPSD 3 26 - - - - - - - - - - 5 5 4 4 5 3 - - - - S122 TIRERPSS AIYPSDS 10 971 107 - 41 40 34 46 64 - 80 48 54 49 44 40 83 19 82 35 89 16 S129 SAIYPSDS FRQSLLG 10 1042 105 - 79 72 11 7 89 - 75 43 83 76 97 88 63 14 37 13 81 9 S133 PSDSFRQS LLGSRRG 9 327 24 - 19 19 - - 64 - 7 2 4 4 44 40 21 5 9 4 47 14 S137 FRQSLLGS RRGRSSL 10 667 17 - 32 21 30 32 81 - 42 24 73 69 21 19 65 12 74 33 20 2 S142 LGSRRGRS SLSLAKS 10 1175 114 - 90 68 25 28 99 - 56 32 98 89 92 84 54 14 85 34 95 18 S143 GSRRGRSS LSLAKSV 10 1351 96 - 82 61 78 83 99 - 102 59 93 85 101 93 83 19 85 37 88 7 S145 RRGRSSLS LAKSVST 2 33 - - - - - - 27 - - - - - - - - - - - 6 - S149 SSLSLAKS VSTTNIA 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S109 NTALQSVS LRSKTTI 4.2e-12 - 0.031 - - 1.1e-7 0.016 7e-8 - - 0.83 S121 TTIRERPS SAIYPSD - - - - - - - - - - - S122 TIRERPSS AIYPSDS 0.27 - 7.5e-6 -0.13 - 5.6e-4 -1.9e-7 -0.031 0.15 6.4e-5 -0.18 S129 SAIYPSDS FRQSLLG 4.3e-16 - 2.7e-8 - - 0.14 0.11 5.1e-16 0.044 0.24 - S133 PSDSFRQS LLGSRRG 4.7e-5 - - - - - - 8.3e-9 - - -0.99 S137 FRQSLLGS RRGRSSL 4.7e-10 - 1.2e-5 0.88 - 8.9e-6 1.8e-3 8.3e-3 0.69 0.18 - S142 LGSRRGRS SLSLAKS 2.2e-34 - 0.15 5.2e-7 - 3.8e-7 2.8e-11 2.9e-16 -0.43 3.4e-10 0.006 S143 GSRRGRSS LSLAKSV 3.7e-12 - 5.3e-13 -4.6e-8 - 9.3e-6 -0.85 2.1e-11 0.66 1.5e-7 - S145 RRGRSSLS LAKSVST - - - - - - - - - - - S149 SSLSLAKS VSTTNIA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S109
S121
S122
S129
S133
S137
S142
S143
S145
S149
S151
T152
T153
S163
S172
S174
T175
S177
S327
S405
T455
S643
S645
S648
T679
S691
T695
S696
T700
S711
S719
S721
S722
S733
S782
S886
S932
S940
S941
T945
S947
S952
S953
S956
S960
T974
S976
S986
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation CCRCC S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation COAD S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation GBM S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation HNSCC S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation LSCC S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation LUAD S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation OV S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation PDAC S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation UCEC S109 S121 S122 S129 S133 S137 S142 S143 S145 S149 S151 T152 T153 S163 S172 S174 T175 S177 S327 S405 T455 S643 S645 S648 T679 S691 T695 S696 T700 S711 S719 S721 S722 S733 S782 S886 S932 S940 S941 T945 S947 S952 S953 S956 S960 T974 S976 S986 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S109
S121
S122
S129
S133
S137
S142
S143
S145
S149
S151
T152
T153
S163
S172
S174
T175
S177
S327
S405
T455
S643
S645
S648
T679
S691
T695
S696
T700
S711
S719
S721
S722
S733
S782
S886
S932
S940
S941
T945
S947
S952
S953
S956
S960
T974
S976
S986
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S109
S121
S122
S129
S133
S137
S142
S143
S145
S149
S151
T152
T153
S163
S172
S174
T175
S177
S327
S405
T455
S643
S645
S648
T679
S691
T695
S696
T700
S711
S719
S721
S722
S733
S782
S886
S932
S940
S941
T945
S947
S952
S953
S956
S960
T974
S976
S986
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.